Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: bacteremia [ICD11:
MA15.0 
];
gastroenteritis [ICD11:
1A40.0 ]
NCBI PubMed ID: 23643833Publication DOI: 10.1016/j.carres.2013.03.029Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: W. Jachymek <jachymek
iitd.pan.wroc.pl>
Institutions: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
Hafnia alvei strain PCM 2670 is a clinical isolate from a patient with chronic reproductive tract infection. The novel structure of the semi-rough lipopolysaccharide was established with the use of NMR spectroscopy and mass spectrometry as well as immunochemical techniques. According to the mass spectrometry data, heptose in the oligosaccharide is partially substituted by glycine. H. alvei PCM 2670 core structure encompasses the common core of H. alvei which is modified with two additional galactose units. The 6-substituted galactose is the O-antigen repeating unit substitution residue. The repeating unit consists of five monosaccharide residues and has the following structure: →2)-β-Galp-(1→6)-α-Glcp-(1→6)-α-GlcpNAc3OAc-(1→4)-α-GalpA-(1→3)-β-GlcpNAc6OAc-(1→6)-core.
NMR, Hafnia alvei, glycine, ESIMS, semi-rough lipopolysaccharide
Structure type: oligomer
Location inside paper: p.72, fig.6
Compound class: core oligosaccharide
Contained glycoepitopes: IEDB_120354,IEDB_123890,IEDB_130650,IEDB_130670,IEDB_133751,IEDB_140088,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_2189047,IEDB_226811,IEDB_983931,SB_192
Methods: 13C NMR, 1H NMR, methylation, NMR-2D, GC-MS, SDS-PAGE, sugar analysis, 31P NMR, ESI-MS, NMR-1D, immunoblotting
Related record ID(s): 29430, 29431, 29433, 29434, 29917
NCBI Taxonomy refs (TaxIDs): 910996,
569Reference(s) to other database(s): GTC:G42986BV
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
report error