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Taxonomic group: bacteria / Proteobacteria (Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: respiratory infections [ICD11: CA45

]; urinary tract infections (UTI) [ICD11: GC08

]; infection due to Klebsiella pneumoniae [ICD11: XN741

]

The structure was elucidated in this paper
NCBI PubMed ID: 23360863
Publication DOI: 10.1016/j.carres.2012.12.018
Journal NLM ID: 0043535
Publisher: Elsevier
Correspondence: kielbj

mail.nih.gov
Institutions: Program on Developmental and Molecular Immunity, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, United States

Carbapenem resistant Klebsiella pneumoniae (CRKP) are isolated with increasing frequency, especially from immunocompromized patients. The capsular polysaccharide (CPS) types of CPKP were not determined. Investigation of two CRKP isolates from a 2011 outbreak at the Clinical Center, the National Institutes of Health, identified a new capsular type shared by the two isolates, similar to K. pneumonia K19 and K34 but structurally different than any published K. pneumoniae CPS repeating unit: The LPS of the two isolates was found to have no O-specific polysaccharide and the chemical structure of the core oligosaccharides agreed with the published data. If this structure type will be prevalent among CPKP isolates, our findings could facilitate rapid diagnosis and help to develop new therapeutic solutions to this antibiotic resistant pathogen.

LPS, structure, capsular polysaccharide, Klebsiella pneumoniae, KPC, CRKP

Structure type: oligomer
Location inside paper: p.37, fig.2
Compound class: core oligosaccharide
Contained glycoepitopes: IEDB_130650,IEDB_130670,IEDB_140087,IEDB_140088,IEDB_140090,IEDB_141807,IEDB_142488,IEDB_146664,IEDB_151531,IEDB_2189047,IEDB_226811,IEDB_983931,SB_192

Methods: 13C NMR, 1H NMR, methylation, NMR-2D, SDS-PAGE, sugar analysis, ESI-MS, mild acid hydrolysis, GC, NMR-1D, immunodiffusion assays

Related record ID(s): 29246, 29624, 29625
NCBI Taxonomy refs (TaxIDs): 573
Reference(s) to other database(s): GTC:G48661BJ
Show glycosyltransferases

There are 2 chemically distinct structures. Please, select:

N[C@H]1[C@@H](O[C@H]2[C@@H](C(=O)O)O[C@H](O[C@@H]3[C@H](O)[C@@H](O[C@@H]4[C@H](O)[C@@H](O[C@@H]5[C@H](O)CC(O)(C(=O)O)O[C@@H]5[C@H](O)CO)O[C@H]([C@@H](O)CO)[C@H]4O[C@@H]4O[C@H](CO[C@@H]5O[C@H](C(=O)O)[C@H](O)[C@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)O[C@H]([C@@H](O)CO[C@H]4O[C@H]([C@@H](O)CO[C@@H]5O[C@H](C(=O)O)[C@H](O)[C@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@@H]4O)[C@H]3O)[C@H](O)[C@H]2O)O[C@H](CO)[C@@H](O)[C@@H]1O

SVG MW SMILES 3D mol Ionize