Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: respiratory infections [ICD11:
CA45 
];
urinary tract infections (UTI) [ICD11:
GC08 ];
infection due to Klebsiella pneumoniae [ICD11:
XN741 ]
NCBI PubMed ID: 23360863Publication DOI: 10.1016/j.carres.2012.12.018Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: kielbj
mail.nih.gov
Institutions: Program on Developmental and Molecular Immunity, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, United States
Carbapenem resistant Klebsiella pneumoniae (CRKP) are isolated with increasing frequency, especially from immunocompromized patients. The capsular polysaccharide (CPS) types of CPKP were not determined. Investigation of two CRKP isolates from a 2011 outbreak at the Clinical Center, the National Institutes of Health, identified a new capsular type shared by the two isolates, similar to K. pneumonia K19 and K34 but structurally different than any published K. pneumoniae CPS repeating unit: The LPS of the two isolates was found to have no O-specific polysaccharide and the chemical structure of the core oligosaccharides agreed with the published data. If this structure type will be prevalent among CPKP isolates, our findings could facilitate rapid diagnosis and help to develop new therapeutic solutions to this antibiotic resistant pathogen.
LPS, structure, capsular polysaccharide, Klebsiella pneumoniae, KPC, CRKP
Structure type: polymer chemical repeating unit
Location inside paper: p.37, fig.2
Compound class: CPS
Contained glycoepitopes: IEDB_133754,IEDB_136105,IEDB_142488,IEDB_146664,IEDB_189517,IEDB_225177,IEDB_885823,IEDB_983931,SB_192
Methods: 13C NMR, 1H NMR, methylation, NMR-2D, SDS-PAGE, sugar analysis, ESI-MS, mild acid hydrolysis, GC, NMR-1D, immunodiffusion assays
Related record ID(s): 29246, 29623, 29624
NCBI Taxonomy refs (TaxIDs): 573Reference(s) to other database(s): GTC:G25480LX, GlycomeDB:
5055
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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