Taxonomic group: bacteria / Firmicutes
(Phylum: Firmicutes)
Host organism: Homo sapiens
Associated disease: diarrhea [ICD11:
ME05.1 
, ICD11:
SA55 ];
infection due to Clostridium difficile [ICD11:
XN0SE ]
The structure was elucidated in this paperPublication DOI: 10.1039/C1CC13614CJournal NLM ID: 9610838Publisher: Cambridge: Royal Society of Chemistry
Correspondence: peter.seeberger
mpikg.mpg.de
Institutions: Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Am Muhlenberg 1, 14476 Potsdam, Germany
Clostridium difficile strain ribotype 027 is a hypervirulent pathogen that is responsible for recent, severe outbreaks of serious nosocomial infections. As a foundation for the development of a preventative carbohydrate-based vaccine, we have synthesized a pentasaccharide cell wall repeating unit from PS-I unique to this strain, by the linear assembly of four monosaccharide building blocks.
synthesis, repeating unit, pentasaccharide, vaccine, nosocomial infections, Clostridium difficile
Structure type: oligomer
Location inside paper: p.10260, fig.1, 1, scheme 4, 1
Aglycon: 5-amino-pentanyl
Trivial name: PS1, cell-surface polysaccharide PS-I
Compound class: cell wall polysaccharide
Contained glycoepitopes: IEDB_136105,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_189515,IEDB_189517,IEDB_225177,IEDB_232583,IEDB_232584,IEDB_232585,IEDB_885823,IEDB_983931,SB_192
Methods: 13C NMR, 1H NMR, chemical synthesis, chemical methods, glycosylation
Synthetic data: chemical
Related record ID(s): 29273
NCBI Taxonomy refs (TaxIDs): 1496Reference(s) to other database(s): GTC:G13367SV
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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(later renamed to: Peptoclostridium difficile O27)