Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: plague [ICD11:
1B93 
, ICD11:
XN6QS ];
infection due to Yersinia pestis [ICD11:
XN6QS ]
The structure was elucidated in this paperPublication DOI: 10.1002/anie.201301633Journal NLM ID: 0370543Publisher: Weinheim: Wiley-VCH
Correspondence: M. Caroff <martine.caroff
u-psud.fr>; peter.seeberger
mpikg.mpg.de
Institutions: Prof. Dr. P. H. Seeberger Institute of Chemistry and Biochemistry Freie Universitt Berlin Arnimallee 22, 14195 Berlin, Germany
The sugar coat of 'Black Death' betrays it. The plague can be detected by monoclonal anti-carbohydrate antibodies. In a new technique, a plague-specific oligosaccharide antigen (see structure) is synthesized. With the help of lipopolysaccharide (LPS)-specific monoclonal antibodies (mAbs), the presence of the plague pathogen Yersinia pestis can then be detected in serum from patients by using a glycan microarray.
lipopolysaccharides, antibodies, Oligosaccharides, Yersinia pestis, pathogen detection
Structure type: oligomer
Location inside paper: p.2, scheme 1, 1, p.3, scheme 4, 1, 20
Aglycon: 5-aminopentyl, diphtheria toxoid CRMM 197
Compound class: core oligosaccharide
Contained glycoepitopes: IEDB_130670,IEDB_140088,IEDB_2189047,IEDB_226811
Methods: 13C NMR, 1H NMR, SDS-PAGE, chemical methods, MALDI-TOF MS, serological methods, conjugation
Synthetic data: chemical
Comments, role: the triheptose motif from the inner core oligosaccharide of the LPS
Related record ID(s): 29425, 29426, 29427
NCBI Taxonomy refs (TaxIDs): 632Reference(s) to other database(s): GTC:G63698SU
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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