Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: infectious gastroenteritis [ICD11:
1A40.Z 
];
diarrhea [ICD11:
ME05.1 , ICD11:
SA55 ];
infection due to Escherichia coli [ICD11:
XN6P4 ]
NCBI PubMed ID: 25318901Publication DOI: 10.1016/j.carres.2014.08.003Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: akmisra69
gmail.com
Institutions: Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII-M, Kolkata 700054, India
The tetrasaccharide repeating unit of the O-antigen of Escherichia coli O174 strain was synthesized applying sequential glycosylations of suitably functionalized monosaccharide intermediates. Activation of glycosyl trichloroacetimidate derivatives using nitrosyl tetrafluoroborate (NOBF4) has been used during the synthesis. The glycosylation steps were high yielding with satisfactory stereo outcome.
synthesis, tetrasaccharide, O-antigen, Escherichia coli, glycosylation, Thioglycoside, Trichloroacetimidate, Nitrosyl tetrafluoroborate
Structure type: suggested polymer biological repeating unit
Location inside paper: p.22, fig.1
Compound class: O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_115136,IEDB_130648,IEDB_134627,IEDB_135813,IEDB_136044,IEDB_137340,IEDB_137472,IEDB_137473,IEDB_140630,IEDB_141794,IEDB_141807,IEDB_147450,IEDB_151531,IEDB_190606,IEDB_423153,SB_165,SB_166,SB_187,SB_195,SB_23,SB_24,SB_7,SB_8,SB_88
Methods: 13C NMR, 1H NMR, NMR-2D, IR, TLC, ESI-MS, chemical synthesis, chemical methods, glycosylation
Synthetic data: chemical
Related record ID(s): 27150, 28862, 29965, 30207
NCBI Taxonomy refs (TaxIDs): 562Reference(s) to other database(s): GTC:G25286AF
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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