Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: legionellosis [ICD11:
1C19 
, ICD11:
XN3SZ ];
infection due to Legionella pneumophila [ICD11:
XN9YS ]
NCBI PubMed ID: 24446310Publication DOI: 10.1002/anie.201309072Journal NLM ID: 0370543Publisher: Weinheim: Wiley-VCH
Correspondence: sdukan
imm.cnrs.fr; boris.vauzeilles
cnrs.fr (Boris Vauzeilles)
Institutions: Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles du CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette (France)
Legionella pneumophila is a pathogenic bacterium involved in regular outbreaks characterized by a relatively high fatality rate and an important societal impact. Frequent monitoring of the presence of this bacterium in environmental water samples is necessary to prevent these epidemic events, but the traditional culture-based detection and identification method requires up to 10 days. Reported herein is a method allowing identification of Legionella pneumophila by metabolic lipopolysaccharide labeling which targets, for the first time, a precursor to monosaccharides that are specifically present within the O-antigen of the bacterium. This new approach allows easy detection of living Legionella pneumophila, while other Legionella species are not labeled.
biosynthesis, carbohydrates, click chemistry, imaging agents, synthesis design
Structure type: homopolymer
Location inside paper: p.1275
Compound class: O-polysaccharide, O-antigen
Methods: 13C NMR, 1H NMR, chemical synthesis, chemical methods, biochemical methods, glycosylation
NCBI Taxonomy refs (TaxIDs): 66976Reference(s) to other database(s): GlycomeDB:
33608
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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