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Taxonomic group: bacteria / Proteobacteria (Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: urinary tract infections (UTI) [ICD11: GC08

]; infection due to Proteus penneri [ICD11: XN7PE

]; infection due to Proteus mirabilis [ICD11: XN9ZF

]

NCBI PubMed ID: 24644555
Journal NLM ID: 14520300R
Publisher: Panstwowe Wydawnictwo Naukowe
Correspondence: agatapal

biol.uni.lodz.pl
Institutions: Department of General Microbiology, Institute of Microbiology, Biotechnology and Immunology, University of Lodz, Lodz, Poland

Most Proteus lipopolysaccharides (LPSs) contain uronic acids or their amides with different amino acids, which together with other negatively charged components account for the acidic character of such LPS molecules. Previous studies have shown the significance of an amide of galacturonic acid with lysine [D-GalA(L-Lys)] for serological specificity of O-antigens from few P. mirabilis strains. In this work, the immunodominant role of GalALys was indicated for the P. penneri 42 LPS core region. The studies also showed the serological identity of core oligosaccharides from P. penneri 42 (O71), P. mirabilis 51/57 (O28) and R14/S1959 strains.

Lipopolysaccharide, Proteus, core region, anti-conjugate serum, amide of galacturonic acid with lysine

Structure type: oligomer
Location inside paper: p.131, fig.2a
Aglycon: lipid A
Compound class: LPS
Contained glycoepitopes: IEDB_120354,IEDB_123890,IEDB_130650,IEDB_130659,IEDB_130670,IEDB_135813,IEDB_136017,IEDB_137340,IEDB_140087,IEDB_140088,IEDB_140090,IEDB_141807,IEDB_142488,IEDB_146664,IEDB_151531,IEDB_2189047,IEDB_226811,IEDB_983931,SB_192

Methods: ELISA, acid hydrolysis, Western blotting, MALDI-TOF MS, conjugation

Related record ID(s): 30421, 30422
NCBI Taxonomy refs (TaxIDs): 102862, 584
Show glycosyltransferases

There is only one chemically distinct structure:

CC(=O)N[C@H]1[C@H](OC[C@H]2O[C@H](O[C@H]3[C@@H](C(=O)O)O[C@H](O[C@@H]4[C@H](O)[C@@H](O[C@@H]5[C@H](O)[C@@H](O[C@@H]6[C@H](O[C@]7(C(=O)O)C[C@@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O7)C[C@](O)(C(=O)O)O[C@@H]6[C@H](O)CO[C@H]6OC[C@H](N)[C@H](O)[C@H]6O)O[C@H]([C@@H](O)CO)[C@H]5O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)O[C@H]([C@H](CO[C@H]5O[C@H]([C@@H](O)CO)[C@@H](O)[C@H](O)[C@@H]5O)OP(=O)(O)OCCN)[C@H]4O)[C@H](O)[C@H]3O)[C@H](NC(=O)CN)[C@@H](O)[C@@H]2O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@@H]1O[C@H](C(=O)N[C@@H](CCCCN)C(=O)O)[C@H](OP(=O)(O)OCCN)[C@H](O)[C@H]1O

SVG MW SMILES 3D mol Ionize