Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: bacillary dysentery (shigellosis) [ICD11:
1A02 
, ICD11:
SA56 , ICD11:
XN7HG ];
infection due to Shigella flexneri [ICD11:
XN7Y2 ]
NCBI PubMed ID: 25327486Publication DOI: 10.1186/s12866-014-0266-7Journal NLM ID: 100966981Publisher: Biomed Central
Correspondence: yknirel
gmail.com
Institutions: N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia, State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, China CDC, P.O. Box 5, Changping, Beijing, China, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney NSW 2052, Australia
O-antigen (O-polysaccharide) of the lipopolysaccharide is a highly variable cell component of the outer membrane in Shigella flexneri. It defines the serospecificity and plays an important role in the pathogenesis of shigellosis. There are two distinct O-antigen forms for the 19 serotypes of S. flexneri: one for serotypes 1-5, X, Y, 7 (and their subtypes), and the other for serotype 6. Although having different basal O-polysaccharide structures, the two forms share a common disaccharide fragment [→2)-α-l-Rhap III-(1 → 2)-α-l-Rhap II]. In serotype 6 and some non-6 serotypes, RhaIII is O-acetylated at position either 3 or 4 (3/4-O-acetylation), conferring to the hosts a novel antigenic determinant named O-factor 9. An acyltransferase gene (oacB) responsible for this modification has been identified in serotypes 1a, 1b, 2a, 5a, and Y, but not in serotype 6.
O-antigen, Shigella flexneri, 3/4-O-acetylation, aAcyltransferase, oacC, anti-O-factor 9 serum
Structure type: polymer chemical repeating unit
Location inside paper: p.266-2
Compound class: O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_130648,IEDB_133754,IEDB_136105,IEDB_137473,IEDB_225177,IEDB_885823
Methods: 13C NMR, 1H NMR, PCR, SDS-PAGE, DNA techniques, Western blotting, serological methods, GPC, bioinformatic analysis
Comments, role: the chain is partially 3-O-acetylated (major type) and partially 4-O-acetylated (minor type)
Related record ID(s): 30083, 30315, 30316, 30317, 30318
NCBI Taxonomy refs (TaxIDs): 424719
Show glycosyltransferases
There is only one chemically distinct structure:
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