Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: urinary tract infections (UTI) [ICD11:
GC08 
];
infection due to Proteus mirabilis [ICD11:
XN9ZF ]
NCBI PubMed ID: 24644555Journal NLM ID: 14520300RPublisher: Panstwowe Wydawnictwo Naukowe
Correspondence: agatapal
biol.uni.lodz.pl
Institutions: Department of General Microbiology, Institute of Microbiology, Biotechnology and Immunology, University of Lodz, Lodz, Poland
Most Proteus lipopolysaccharides (LPSs) contain uronic acids or their amides with different amino acids, which together with other negatively charged components account for the acidic character of such LPS molecules. Previous studies have shown the significance of an amide of galacturonic acid with lysine [D-GalA(L-Lys)] for serological specificity of O-antigens from few P. mirabilis strains. In this work, the immunodominant role of GalALys was indicated for the P. penneri 42 LPS core region. The studies also showed the serological identity of core oligosaccharides from P. penneri 42 (O71), P. mirabilis 51/57 (O28) and R14/S1959 strains.
Lipopolysaccharide, Proteus, core region, anti-conjugate serum, amide of galacturonic acid with lysine
Structure type: polymer biological repeating unit
Location inside paper: p.131, fig.2c
Aglycon: lipid A
Compound class: O-polysaccharide
Contained glycoepitopes: IEDB_115136,IEDB_130648,IEDB_136017,IEDB_137473,IEDB_140630,IEDB_153510,IEDB_423153,IEDB_733911
Methods: ELISA, acid hydrolysis, Western blotting, MALDI-TOF MS, conjugation
Related record ID(s): 30112, 30421
NCBI Taxonomy refs (TaxIDs): 584
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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