Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Escherichia coli [ICD11:
XN6P4 
]
Publication DOI: 10.1038/nchembio.1525Journal NLM ID: 101231976Publisher: New York, NY: Nature Publishing Group
Correspondence: jpaulson
scripps.edu; rdcummi
emory.edu
Institutions: Department of Biochemistry and the Glycomics Center, Emory University School of Medicine, Atlanta, Georgia, USA, Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA, Department of and Chemical Physiology, The Scripps Research Institute, La Jolla, California, USA
Genomic approaches continue to provide unprecedented insight into the microbiome, yet host immune interactions with diverse microbiota can be difficult to study. We therefore generated a microbial microarray containing defined antigens isolated from a broad range of microbial flora to examine adaptive and innate immunity. Serological studies with this microarray show that immunoglobulins from multiple mammalian species have unique patterns of reactivity, whereas exposure of animals to distinct microbes induces specific serological recognition. Although adaptive immunity exhibited plasticity toward microbial antigens, immunological tolerance limits reactivity toward self. We discovered that several innate immune galectins show specific recognition of microbes that express self-like antigens, leading to direct killing of a broad range of Gram-negative and Gram-positive microbes. Thus, host protection against microbes seems to represent a balance between adaptive and innate immunity to defend against evolving antigenic determinants while protecting against molecular mimicry.
molecular mimicry, glycan, interaction, Gram-negative, galectins, Gram-positive, innate immunity, Glycomics
Structure type: fragment of a bigger structure
Location inside paper: p.427, Suppl-Fig. 4, E. coli O86:B7
Trivial name: microbial carbohydrate determinants
Compound class: O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_115013,IEDB_130645,IEDB_130648,IEDB_134627,IEDB_136044,IEDB_136045,IEDB_136906,IEDB_137472,IEDB_137473,IEDB_1391961,IEDB_1391963,IEDB_140125,IEDB_141584,IEDB_141794,IEDB_142489,IEDB_143260,IEDB_144562,IEDB_149558,IEDB_150766,IEDB_150948,IEDB_150952,IEDB_151528,IEDB_152212,IEDB_152214,IEDB_153553,IEDB_174333,IEDB_190606,IEDB_241096,IEDB_461710,IEDB_461718,IEDB_461719,IEDB_885822,IEDB_918314,SB_148,SB_154,SB_165,SB_166,SB_187,SB_195,SB_23,SB_24,SB_7,SB_8,SB_86,SB_87,SB_88
Methods: serological methods
Biological activity: examination of galectin-3 (Gal-3), galectin-4 (Gal-4) and galectin-8 (Gal-8) on the MGM
Comments, role: -2)aDGalp(1-3)[aLFucp(1-2)]bDGalp(1-3)[Ac(1-2)]aDGalpN(1-3)[Ac(1-2)]aDGalpN(1- O-antigen structure of the Escherichia coli O86:B7.
Related record ID(s): 30138, 30474, 30477, 30478, 30479, 30480
NCBI Taxonomy refs (TaxIDs): 2162909Reference(s) to other database(s): GTC:G72643BS
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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