Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: nosocomial infections [ICD11:
XB25 
];
infection due to Acinetobacter [ICD11:
XN25B ]
NCBI PubMed ID: 25496419Publication DOI: 10.1021/ol5033128Journal NLM ID: 100890393Publisher: American Chemical Society
Correspondence: paul.kosma
boku.ac.at
Institutions: Department of Chemistry, University of Natural Resources and Life Sciences-Vienna, Muthgasse 18, A-1190 Vienna, Austria
Resistance of bacterial pathogens toward antibiotics has revived interest in lipopolysaccharide (LPS) motifs as potential therapeutic targets. The LPS of several pathogenic Acinetobacter strains comprises a 4,5-branched Kdo trisaccharide containing an uncommon (2→5)-linkage. In this contribution the first stereoselective glycosylation method for obtaining an α-Kdo-(2→5)-α-Kdo disaccharide in good yield is highlighted. The synthetic approach used for accessing this linkage type will allow for future studies of the immunoreactivity associated with this unique bacterial Kdo inner core structure.
Lipopolysaccharide, 3-deoxy-D-manno-oct-2-ulosonic acid, Acinetobacter, Kdo, inner core, glycosylation, immunoreactivity
Structure type: fragment of a bigger structure
Location inside paper: p.110
Compound class: core oligosaccharide
Contained glycoepitopes: IEDB_130650,IEDB_130659
Methods: 13C NMR, 1H NMR, NMR-2D, TLC, ESI-MS, chemical synthesis, chemical methods, NMR-1D, glycosylation
Comments, role: One of origins: Acinetobacter sp. without species and strain assignment.
Related record ID(s): 30842
NCBI Taxonomy refs (TaxIDs): 40216,
469Reference(s) to other database(s): GTC:G59760SO
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There is only one chemically distinct structure:
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