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Taxonomic group: bacteria / Proteobacteria (Phylum: Proteobacteria)
Associated disease: infection due to Coxiella burnetii [ICD11: XN0QS

]

NCBI PubMed ID: 23600879
Publication DOI: 10.4149/av_2013_02_229
Journal NLM ID: 0370401
Publisher: Bratislava, Slovak Republic: AEPress, Ltd
Correspondence: virutoma

savba.sk
Institutions: Institute of Virology, Slovak Academy of Sciences, Dúbravská cesta 9, 845 05 Bratislava, Slovak Republic

Coxiella burnetii is an intracellular, Gram-negative bacterium and causative agent of Q fever. In humans, the disease ranges mostly from a flu-like illness and self-recovering mild pneumonia to severe meningoencephalitis, myocarditis or endocarditis. Recent molecular and biochemical/immunological advances, along with improved instrumentation, have provided unique insight into the host-parasite interrelationship and revealed previously unknown virulence strategies of C. burnetii. Noticeable progress has also been achieved in gaining a better understanding of the role of two major outer membrane components - lipopolysaccharide (LPS) and proteins in the life and immunopathobiology of the bacterium. Detailed glycomic studies have brought indispensable structural and functional information on LPS and its role in pathogenesis and immunity of Q fever. Recent proteomic studies have brought a deeper insight into the pathogen`s physiology, virulence and development and offered new possibilities in the investigation of inter/intra-species variation. This review will focus on advances in glycomics and proteomics of C. burnetii providing information on unique glycan and protein species, which together with other findings in the field, might lead to both a better understanding of this unusual pathogen and improvements in Q fever diagnosis and therapy.

Lipopolysaccharide, LPS, virulence, Coxiella burnetii, detection, Glycomics, Proteomics, diagnosis, Q fever

Structure type: oligomer
Location inside paper: p.232
Compound class: LPS
Contained glycoepitopes: IEDB_130650,IEDB_130659,IEDB_130701,IEDB_135394,IEDB_135515,IEDB_140092,IEDB_141807,IEDB_144983,IEDB_150901,IEDB_150908,IEDB_151531,IEDB_152206,IEDB_2189046,IEDB_983930,SB_44,SB_67,SB_72

Comments, role: review; LPS II form C. burnetii in avirulent phase II; LIP = C14 - C16 (Myr - Pam or 3HOMyr - 3HOPam).

NCBI Taxonomy refs (TaxIDs): 777
Show glycosyltransferases

There is only one chemically distinct structure:

[1*]O[C@H]1[C@H](O)[C@@H](CO[C@@H]2O[C@H](CO[C@]3(C(=O)O)C[C@@H](O[C@]4(C(=O)O)C[C@@H](O[C@]5(C(=O)O)C[C@@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O5)[C@@H](O)[C@@H]([C@H](O)CO)O4)[C@@H](O[C@H]4O[C@H]([C@H](O)CO)[C@@H](O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O)[C@H](O[C@H]5O[C@H]([C@H](O)CO)[C@@H](O)[C@H](O)[C@@H]5O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O)[C@@H]4O)[C@@H]([C@H](O)CO)O3)[C@@H](OP(=O)(O)O)[C@H](O[1*])[C@H]2NC(=O)CC(O)CCCCCCCCCCCCC)O[C@H](OP(=O)(O)O)[C@@H]1NC(=O)CC(O)CCCCCCCCCCCCC

SVG MW SMILES 3D mol Ionize

R1 = LIP