Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: nosocomial infections [ICD11:
XB25 
];
infection due to Acinetobacter [ICD11:
XN25B ]
The structure was elucidated in this paperNCBI PubMed ID: 25496419Publication DOI: 10.1021/ol5033128Journal NLM ID: 100890393Publisher: American Chemical Society
Correspondence: paul.kosma
boku.ac.at
Institutions: Department of Chemistry, University of Natural Resources and Life Sciences-Vienna, Muthgasse 18, A-1190 Vienna, Austria
Resistance of bacterial pathogens toward antibiotics has revived interest in lipopolysaccharide (LPS) motifs as potential therapeutic targets. The LPS of several pathogenic Acinetobacter strains comprises a 4,5-branched Kdo trisaccharide containing an uncommon (2→5)-linkage. In this contribution the first stereoselective glycosylation method for obtaining an α-Kdo-(2→5)-α-Kdo disaccharide in good yield is highlighted. The synthetic approach used for accessing this linkage type will allow for future studies of the immunoreactivity associated with this unique bacterial Kdo inner core structure.
Lipopolysaccharide, 3-deoxy-D-manno-oct-2-ulosonic acid, Acinetobacter, Kdo, inner core, glycosylation, immunoreactivity
Structure type: oligomer
Location inside paper: p.110, p.112, scheme 4, compound 24
Compound class: core oligosaccharide
Contained glycoepitopes: IEDB_130650
Methods: 13C NMR, 1H NMR, NMR-2D, TLC, ESI-MS, chemical synthesis, chemical methods, NMR-1D, glycosylation
Synthetic data: chemical
Comments, role: Origin: Acinetobacter sp. without species and strain assignment.
Related record ID(s): 30658
NCBI Taxonomy refs (TaxIDs): 40216,
469
Show glycosyltransferases
1H NMR data: present in publication
|
13C NMR data: present in publication
|
There is only one chemically distinct structure:
Found 
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