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Taxonomic group: bacteria / Proteobacteria (Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: urinary tract infections (UTI) [ICD11: GC08

]; infection due to Morganella [ICD11: XN8G6

]

The structure was elucidated in this paper
NCBI PubMed ID: 25498024
Publication DOI: 10.1016/j.carres.2014.10.032
Journal NLM ID: 0043535
Publisher: Elsevier
Correspondence: Evguenii.Vinogradov

nrc-cnrc.gc.ca
Institutions: Human Health Therapeutics Portfolio, National Research Council of Canada, 100 Sussex Drive, Ottawa, ON K1A 0R6, Canada, Public Health Agency of Canada, Toronto, ON, Canada

The core region of the lipopolysaccharide of Morganella morganii serotype O:1ab was obtained by hydrolysis of the LPS and studied by 2D NMR, ESI MS, and chemical methods. Its structure was highly homologous to those from the two major members of the same Proteeae tribe, Proteus mirabilis and Providencia alcalifaciens, and analysis of the M. morganii genome disclosed that the loci for its outer core, lipid A and Ara4N moieties are similarly conserved.

LPS, core, Morganella morganii, carbohydrate gene loci

Structure type: oligomer
Location inside paper: p.233, fig.2, oligosaccharide 3
Compound class: core oligosaccharide
Contained glycoepitopes: IEDB_120354,IEDB_123890,IEDB_130650,IEDB_130659,IEDB_130670,IEDB_140087,IEDB_140088,IEDB_140090,IEDB_141807,IEDB_142488,IEDB_146664,IEDB_151531,IEDB_2189047,IEDB_226811,IEDB_241118,IEDB_983931,SB_192

Methods: 13C NMR, 1H NMR, methylation, NMR-2D, DNA sequencing, GC-MS, de-O-acylation, sugar analysis, dephosphorylation, 31P NMR, ESI-MS, acid hydrolysis, HPAEC, GC, deamination, GPC, UV
Comments, role: Oligosaccharide 3 was isolated from mixture of deacylated compounds after complete deacylation of the LPS.

Related record ID(s): 30687, 30888
NCBI Taxonomy refs (TaxIDs): 582
Show glycosyltransferases

There are 2 chemically distinct structures. Please, select:

NCCOP(=O)(O)OC[C@H]1O[C@@H](O[C@@H]2[C@@H](O[C@@H]3[C@H](O)[C@@H](O[C@H]4[C@@H]([C@H](O)CO[C@H]5OC[C@H](N)[C@H](O)[C@H]5O)O[C@@](OC[C@H]5O[C@@H](OC[C@H]6O[C@H](OP(=O)(O)O)[C@H](N)[C@@H](O)[C@@H]6O)[C@H](N)[C@@H](O)[C@@H]5O)(C(=O)O)C[C@H]4O[C@]4(C(=O)O)C[C@@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O4)O[C@H]([C@@H](O)CO)[C@H]3O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)O[C@H]([C@@H](O)CO[C@H]3O[C@H]([C@@H](O)CO)[C@@H](O)[C@H](O)[C@@H]3O)[C@@H](O)[C@@H]2O[C@H]2OC(C(=O)O)=C[C@@H](O)[C@@H]2O[C@H]2O[C@H]([C@@H](O)CO)[C@@H](O)[C@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

SVG MW SMILES 3D mol Ionize