Taxonomic group: bacteria / Proteobacteria, Proteobacteria, Proteobacteria, Proteobacteria, Firmicutes
(Phylum: Proteobacteria, Proteobacteria, Proteobacteria, Proteobacteria, Firmicutes)
Host organism: Homo sapiens
Associated disease: nosocomial infections [ICD11:
XB25 
];
infection due to Acinetobacter baumannii [ICD11:
XN8LS ];
infection due to Escherichia coli [ICD11:
XN6P4 ];
infection due to Yersinia pestis [ICD11:
XN6QS ];
infection due to Staphylococcus epidermidis [ICD11:
XN8KJ ]
NCBI PubMed ID: 26531136Publication DOI: 10.1016/j.carres.2015.10.001Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: denis.giguere
chm.ulaval.ca
Institutions: Département de Chimie, Université Laval, Québec City, Québec, Canada G1V 0A6
The emergence of multidrug-resistance Acinetobacter baumannii requires novel approaches for prevention, treatment and diagnosis. The structures of surface polysaccharides from A. baumannii are valuable tools to understand pathogenesis, virulence and immunogenicity. The synthesis of bacterial mono- or polysaccharides may result in novel probes to become important therapeutic options in the fight against A. baumannii. This report exemplifies the relevance of glycochemistry for the development of new antibiotics.
lipopolysaccharides, capsular polysaccharides, Acinetobacter, Acinetobacter baumannii, polysaccharide synthesis, surface polysaccharides
Structure type: homopolymer ; n=9
Location inside paper: p.37, scheme 6, compound 36, scheme 7 compounds 40 and 42
Aglycon: 3-(4-(acetylthio)butyrylamino)propyl or spacer + carrier protein (Tetanus Toxoid)
Trivial name: PNAG
Contained glycoepitopes: IEDB_135813,IEDB_137340,IEDB_141807,IEDB_151531,IEDB_753248
Synthetic data: chemical
Comments, role: minireview
NCBI Taxonomy refs (TaxIDs): 470,
562,
632,
714,
1282Reference(s) to other database(s): GTC:G11006VI
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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