Taxonomic group: bacteria / Chlamydiae
(Phylum: Chlamydiae)
Associated disease: infection due to Chlamydia trachomatis [ICD11:
XN4Q4 
];
infection due to Chlamydia pneumoniae [ICD11:
XN9EE ]
NCBI PubMed ID: 11521077Publication DOI: 10.1177/09680519010070010301Journal NLM ID: 9433350Publisher: Maney Publishing
Correspondence: sgronow
fz-borstel.de
Institutions: Division of Medical and Biochemical Microbiology, Research Center Borstel, Center for Medicine and Biosciences, Borstel, Germany
A detailed knowledge of LPS biosynthesis is of the utmost importance in understanding the function of the outer membrane of Gram-negative bacteria. The regulation of LPS biosynthesis affects many more compartments of the bacterial cell than the outer membrane and thus contributes to the understanding of the physiology of Gram-negative bacteria in general, on the basis of which only mechanisms of virulence and antibiotic resistance can be studied to find new targets for antibacterial treatment. The study of LPS biosynthesis is also an excellent example to demonstrate the limitations of 'genomics' and 'proteomics', since secondary gene products can be studied only by the combined tools of molecular genetics, enzymology and analytical structural biochemistry. Thus, the door to the field of 'glycomics' is opened.
Lipopolysaccharide, biosynthesis, lipopolysaccharides, LPS, metabolism, microbiology, lipopolysaccharide biosynthesis, gram negative bacteria, membrane
Structure type: fragment of a bigger structure
Location inside paper: p.5
Aglycon: lipid A
Trivial name: inner core
Compound class: core oligosaccharide
Contained glycoepitopes: IEDB_130650,IEDB_130657,IEDB_130658,IEDB_130659
Biological activity: LPS biosynthesis data
Comments, role: review
Related record ID(s): 444, 31646, 31648, 31649, 31650
NCBI Taxonomy refs (TaxIDs): 813,
83558Reference(s) to other database(s): GTC:G30068VP
Show glycosyltransferases
There is only one chemically distinct structure:
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