Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Escherichia coli [ICD11:
XN6P4 
]
NCBI PubMed ID: 31913385Publication DOI: 10.1039/c9ob02433fJournal NLM ID: 101154995Publisher: The Royal Society of Chemistry
Correspondence: martin.fascione
york.ac.uk
Institutions: Department of Chemistry, University of York, York, YO10 5DD, UK
The non-mammalian nonulosonic acid sugar pseudaminic acid (Pse) is present on the surface of a number of human pathogens including Campylobacter jejuni and Helicobacter pylori and other bacteria such as multidrug resistant Acinetobacter baumannii. It is likely important for evasion of the host immune sysyem, and also plays a role in bacterial motility through flagellin glycosylation. Herein we review the mechanistic and structural characterisation of the enzymes responsible for the biosynthesis of the Pse parent structure, Pse5Ac7Ac in bacteria.
biosynthesis, structure, Acinetobacter baumannii, Campylobacter jejuni, pseudaminic acid, nonulosonic acid, Helicobacter pylori, structural studies, Enzymes, glycosylation, immune, Flagellin
Structure type: suggested polymer biological repeating unit
Location inside paper: p.800, fig.3, structure 4
Compound class: O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_130646,IEDB_135813,IEDB_136044,IEDB_137340,IEDB_137472,IEDB_140108,IEDB_140122,IEDB_141794,IEDB_141807,IEDB_151531,IEDB_190606,SB_165,SB_166,SB_187,SB_195,SB_30,SB_7,SB_88
Comments, role: review
3D data: 3D data
NCBI Taxonomy refs (TaxIDs): 2072457Reference(s) to other database(s): GTC:G06517ZV, GlycomeDB:
26491
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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