Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Burkholderia pseudomallei [ICD11:
XN3LD 
];
infection due to Pseudomonas pseudomallei [ICD11:
XN8AA ]
The structure was elucidated in this paperNCBI PubMed ID: 9294419Publication DOI: 10.1128/jb.179.18.5663-5669.1997Journal NLM ID: 2985120RPublisher: American Society for Microbiology
Institutions: Departmentof Microbiology and Infectious Diseases, Heslth Science Centre, Calgary, Canada
Burkholderia (Pseudomonas) pseudomallei is the causative agent of melioidosis, a bacterial infection of considerable morbidity in areas of endemicity of Southeast Asia and northern Australia. Clinical isolates of B. pseudomallei have been demonstrated to produce a lipopolysaccharide (LPS) containing two separate and chemically distinct antigenic O polysaccharides against which infected patients produced antibodies. A putative capsular polysaccharide (CPS) has also been reported and is thought to be antigenically conserved based on results of serological studies with clinical B. pseudomallei isolates. In the present study, the CPS isolated from B. pseudomallei 304b from northeastern Thailand was found to have an [α]D of +99 degrees (water), was composed of D-galactose (D-Gal), 3-deoxy-D-manno-2-octulosonic acid (KDO), and O-acetyl 3:1:1), and was a linear unbranched polymer of repeating tetrasaccharide units having the following structure: -3)-2-O-Ac-β-D-Galp-(1-4)-α-D-Galp-(1-3)-β-D-Galp-(1-5)-β-D-KDOp-(2-. Sera from 13 of 15 patients with different clinical manifestations of melioidosis but not normal controls recognize the CPS, which suggests that it is immunogenic and raises the possibility that it may have a role as a vaccine candidate and/or diagnostic agent.
structure, capsular, characterization, polysaccharide, Burkholderia, Pseudomonas, Kdo, capsular polysaccharide
Structure type: oligomer
Location inside paper: Fig.5
Contained glycoepitopes: IEDB_115013,IEDB_130645,IEDB_136044,IEDB_136906,IEDB_137472,IEDB_141794,IEDB_149558,IEDB_151528,IEDB_190606,IEDB_918314,SB_165,SB_166,SB_187,SB_195,SB_36,SB_7,SB_87,SB_88,SB_9
Methods: NMR, MS
Biological activity: serological data
Comments, role: formerly Pseudomonas pseudomallei
Related record ID(s): 3412, 3589
NCBI Taxonomy refs (TaxIDs): 28450
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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(previously named: Pseudomonas pseudomallei 304b)