Taxonomic group: bacteria / Firmicutes
(Phylum: Firmicutes)
Host organism: Homo sapiens
Associated disease: infection due to Streptococcus pneumoniae [ICD11:
XN3PW 
]
NCBI PubMed ID: 33388123Publication DOI: 10.1016/j.ddtec.2020.08.002Journal NLM ID: 101235076Publisher: Oxford: Elsevier
Institutions: CIC bioGUNE, Basque Research Technology Alliance, BRTA, Bizkaia Technology Park, Building 800, 48160 Derio, Spain, Ikerbasque, Basque Foundation for Science, 48009 Bilbao, Spain, Department Organic Chemistry II, Faculty of Science and technology, UPV-EHU, 48940 Leioa, Spain
Bacterial infections are the cause of different severe health conditions and new therapies to combat these pathogens have been widely investigated. Carbohydrates, being complex structures covering the surface of bacteria, are considered relevant targets for antibody and vaccine development. The biological activities in pathogenesis of bacterial capsular polysaccharides and lipopolysaccharides and their unique structures have boosted the study of the minimal antigenic binding epitopes and the structural details of antibody-carbohydrate recognition. This review describes the most recent advances on the field, examining the structure, conformation and dynamics of relevant bacterial carbohydrates and their complexes with antibodies. The understanding of key factors governing the recognition process is fundamental for the progress toward the development of specific and efficient bacterial therapeutics.
conformation, structure, capsular polysaccharides, epitope, recognition, dynamics, binding, vaccine, bacterial infection
Structure type: fragment of a bigger structure
Location inside paper: Fig.3(b), Pn 14
Trivial name: repeating unit of CPS
Compound class: CPS
Contained glycoepitopes: IEDB_130646,IEDB_135813,IEDB_136044,IEDB_137340,IEDB_137472,IEDB_140108,IEDB_140122,IEDB_141794,IEDB_141807,IEDB_142487,IEDB_142488,IEDB_146664,IEDB_149138,IEDB_149143,IEDB_151531,IEDB_190606,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_30,SB_6,SB_7,SB_88
Comments, role: review
NCBI Taxonomy refs (TaxIDs): 1313Reference(s) to other database(s): GTC:G09494DM
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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