Taxonomic group: bacteria / Firmicutes
(Phylum: Firmicutes)
Associated disease: infection due to Streptococcus pneumoniae [ICD11:
XN3PW 
]
NCBI PubMed ID: 10498742Journal NLM ID: 2985120RPublisher: American Society for Microbiology
Correspondence: e.garsia
cib.csic.es
Institutions: Centra de Investigaciones Biologicas, CSIC and Pharma Mar, Madrid, Spain, and Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina
The complete nucleotide sequence of the capsular gene cluster (cap8) responsible for the biosynthesis of the capsular polysaccharide of Streptococcus pneumoniae type 8 has been determined. The cap8 gene cluster, located between the genes dexB and aliA, is composed of 12 open reading frames. A 14.7-kb DNA fragment embracing the cap8 genes was sufficient to transform an unencapsulated type 3 S. pneumoniae strain to a strain with the type 8 capsule. A possible scenario for the evolution of pneumococcal types 2 and 8 is outlined
biosynthesis, gene, Bacterial, genetics, pathogenicity, DNA, strain, Support, Non-U.S.Gov't, capsular, characterization, polysaccharide, Streptococcus, Streptococcus pneumoniae, capsular polysaccharide, type, Carbohydrate Sequence, Molecular Sequence Data, cluster, gene cluster, Genes, Multigene Family, polysaccharides, Open Reading Frames, sequence, capsule, fragment, Base Sequence, pneumococcal, Sequence Homology, Spain, Comparative Study, evolution, Nucleic Acid
Structure type: polymer chemical repeating unit
Location inside paper: Fig. 1
Compound class: CPS
Contained glycoepitopes: IEDB_115136,IEDB_136906,IEDB_137472,IEDB_140630,IEDB_141794,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_151528,IEDB_190606,IEDB_423153,IEDB_983931,SB_192,SB_7
Biosynthesis and genetic data: genetic data
Related record ID(s): 938, 3886, 6401, 131372, 148808
NCBI Taxonomy refs (TaxIDs): 1313Reference(s) to other database(s): GTC:G02330RW, GlycomeDB:
9627
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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