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Taxonomic group: fungi / Ascomycota (Phylum: Ascomycota)
Associated disease: infection due to Aspergillus fumigatus [ICD11: XN5Z7

]

Publication DOI: 10.1080/mmy.39.1.9.17
Journal NLM ID: 9815835
Publisher: Oxford: Oxford University Press
Correspondence: jplatge

pasteur.fr
Institutions: Unité des Aspergillus, Institut Pasteur, Paris, France

Analysis of the cell wall of Aspergillus fumigatus is guided by obvious biological reasons: the cell wall protects the fungus against the aggressive human defense reactions, it harbours most of the fungal antigens and it represents a potential drug target. This review will discuss our current understanding of the structural organization of the polysaccharides constitutive of the cell wall of A. fumigatus [α and β(1,3)-glucans, chitin, galactomannan, and β(1,3),(1,4)-glucan] and of the enzymes (synthases, transglycosidases, and glycosyl hydrolases) responsible for their biosynthesis and remodelling. Comparative analysis of the cell wall of the conidium and mycelium also provides insights on their respective roles during the pathogenic life of this fungal species.

transferase, cell wall, synthase, hydrolase, Aspergillus fumigatus, conidium, mycelium

Structure type: structural motif or average structure
Location inside paper: fig. 2
Contained glycoepitopes: IEDB_115576,IEDB_128161,IEDB_130701,IEDB_133966,IEDB_134620,IEDB_134621,IEDB_135614,IEDB_136095,IEDB_136104,IEDB_137472,IEDB_137485,IEDB_1394182,IEDB_1397514,IEDB_140116,IEDB_140628,IEDB_140629,IEDB_141111,IEDB_141793,IEDB_141795,IEDB_141806,IEDB_141807,IEDB_141828,IEDB_141829,IEDB_141830,IEDB_141832,IEDB_141833,IEDB_141834,IEDB_142357,IEDB_142488,IEDB_143632,IEDB_144983,IEDB_144994,IEDB_144995,IEDB_144998,IEDB_146664,IEDB_147452,IEDB_147453,IEDB_147454,IEDB_149137,IEDB_149176,IEDB_151531,IEDB_152206,IEDB_153220,IEDB_153543,IEDB_153755,IEDB_153756,IEDB_1539315,IEDB_158538,IEDB_158555,IEDB_161166,IEDB_164174,IEDB_164175,IEDB_164176,IEDB_164479,IEDB_164480,IEDB_174840,IEDB_190606,IEDB_2278476,IEDB_2278477,IEDB_2278480,IEDB_232584,IEDB_232585,IEDB_2346541,IEDB_241101,IEDB_420417,IEDB_420418,IEDB_420419,IEDB_420420,IEDB_420421,IEDB_423115,IEDB_558866,IEDB_558867,IEDB_558868,IEDB_558869,IEDB_742521,IEDB_76933,IEDB_857742,IEDB_857743,IEDB_885812,IEDB_983930,IEDB_983931,SB_136,SB_191,SB_192,SB_196,SB_197,SB_198,SB_4

Synthetic data: enzymatic in vivo
Comments, role: review; possible structure

NCBI Taxonomy refs (TaxIDs): 746128
Show glycosyltransferases

SMILES errors: ??Man?(1-?)??Man?(1-?)a?Man?(1-2)a?Man?(1-2)a?Man?(1-2)[??Galf(1-?)??Galf(1-?)??Galf(1-?)b?Galf(1-5)??Galf(1-?)]a?Man?(1-6)a?Man?(1-2)[??Galf(1-?)??Galf(1-?)??Galf(1-?)b?Galf(1-5)??Galf(1-?)]a?Man?(1-2)??Man?(1-6)??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)b?Glc?(1-3)??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)[b?Glc?N(1-4)b?Glc?N(1-4)b?Glc?N(1-4)b?Glc?N(1-4)b?Glc?N(1-4)b?Glc?N(1-4)??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)b?Glc?(1-3)??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)[??Glc?(1-?)??Glc?(1-?)b?Glc?(1-3)??Glc?(1-?)[??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)]??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)b?Glc?(1-6)[??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)[??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)]??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)b?Glc?(1-6)[??Glc?(1-?)??Glc?(1-?)b?Glc?(1-3)??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)[??Glc?(1-4)b?Glc?(1-3)b?Glc?(1-4)b?Glc?(1-3)b?Glc?(1-4)b?Glc?(1-3)b?Glc?(1-3)??Glc?(1-?)]??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)]??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)]??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)]??Glc?(1-?)b?Glc?(1-3)b?Glc?(1-3)??Glc?(1-?)]??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)??Glc?(1-?)??Glc?:
SMILES error: number of atoms (~1123) exceeds a structural formula limit (500)