Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
Associated disease: infection due to Cryptococcus neoformans [ICD11:
XN3EH 
]
Publication DOI: 10.1080/mmy.39.1.19.30Journal NLM ID: 9815835Publisher: Oxford: Oxford University Press
Correspondence: Arturo Casadevall <casadeva
aecom.yu.edu>
Institutions: Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Melanization is a property that is shared among several human pathogenic fungi, whereas encapsulation is a property unique to Cryptococcus neoformans. Focusing on C. neoformans, the current knowledge of the structure and synthesis of the melanin and polysaccharide capsule is discussed. The importance of such basic biological information is underscored by the involvement of each to the pathogenic ability of the fungus and their potential as drug targets, yet areas where critical data remain elusive are clearly visible. Finally, in recognition of the fact that C. neoformans is a free-living organism, we conclude by examining the possible biological importance of each of these traits for environmental survival of the fungus.
virulence, Basidiomycetes, Glucuronoxylomannan, galactoxylomannan, laccase
Structure type: fragment of a bigger structure
Location inside paper: fig. 2b (GalXM)
Contained glycoepitopes: IEDB_130701,IEDB_136044,IEDB_136095,IEDB_137472,IEDB_141794,IEDB_144983,IEDB_152206,IEDB_164174,IEDB_190606,IEDB_983930,SB_165,SB_166,SB_187,SB_195,SB_197,SB_44,SB_67,SB_7,SB_72,SB_88
Comments, role: review; possible side chain of ID 40730
Related record ID(s): 40516, 40725, 40726, 40727, 40728, 40729, 40730, 40731
NCBI Taxonomy refs (TaxIDs): 5207
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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