Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
Associated disease: infection due to Cryptococcus neoformans [ICD11:
XN3EH 
]
Publication DOI: 10.1016/S0966-842X(00)01890-4Journal NLM ID: 9310916Publisher: Cambridge: Elsevier Trends Journals
Correspondence: doering
borcim.wustl.edu
Institutions: Dept of Molecular Microbiology, Washington University School of Medicine, Campus 8230, 660 South Euclid Ave, St Louis, MO 63110, USA
During the past few decades, increasing attention has focused on pathogenic fungi both as fascinating research subjects and as the agents of serious illness in diverse patient populations. In particular, opportunistic fungi such as Cryptococcus neoformans command notice as the ranks of their immunocompromised victims grow. C. neoformans is unique among fungal pathogens for its major virulence factor, a complex polysaccharide capsule. In this article, our current understanding of the structure and biosynthesis of the capsule is reviewed, as are the many questions that remain to be answered about how Cryptococcus gets its coat.
polysaccharide, capsule, Cryptococcus neoformans, cryptococcosis, glycan synthesis
Structure type: suggested polymer biological repeating unit
Location inside paper: Fig. 4a
Trivial name: glucuronoxylomannan (GXM)
Compound class: CPS, EPS, O-polysaccharide, O-antigen, cell wall polysaccharide, polysaccharide, glucuronoxylomannan, capsule polysaccharide
Contained glycoepitopes: IEDB_114701,IEDB_115136,IEDB_115576,IEDB_130701,IEDB_140116,IEDB_140630,IEDB_144983,IEDB_145668,IEDB_152206,IEDB_164174,IEDB_167188,IEDB_174332,IEDB_2270799,IEDB_423153,IEDB_76933,IEDB_983930,SB_197,SB_44,SB_67,SB_72
Comments, role: review; chemotype M2; 6-O-acetylation modifies up to 10% of mannose residues. Chemical repeating unit frame was shifted in annotation for compatibility with structures elucidated by MS [Eukaryotic Cell 2007, 6: 1464-1473].
Related record ID(s): 40552, 40816, 40817, 40818, 43807, 43815, 43819
NCBI Taxonomy refs (TaxIDs): 178876Reference(s) to other database(s): GTC:G75580HK, CCSD:
50376, CBank-STR:15059
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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(later renamed to: Cryptococcus neoformans var. grubii)