Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Organ / tissue: cell wall
NCBI PubMed ID: 34746525Publication DOI: 10.1016/j.tcsw.2021.100063Journal NLM ID: 101728565Publisher: Amsterdam: Elsevier
Correspondence: sanaz.ahmadipour
manchester.ac.uk
Institutions: Department of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, Manchester, UK, Iceni Diagnostics Ltd, The Innovation Centre, Norwich Research Park, Norwich, UK, Lennard-Jones Laboratory, School of Chemical and Physical Sciences, Keele University, Keele, UK
The impact of fungal infections on humans is a serious public health issue that has received much less attention than bacterial infection and treatment, despite ever-increasing incidence exacerbated by an increased incidence of immunocompromised individuals in the population. Candida species, in particular, cause some of the most prevalent hospital-related fungal infections. Fungal infections are also detrimental to the well-being of grazing livestock, with milk production in dairy cows, and body and coat condition adversely affected by fungal infections. Fungal cell walls are essential for viability, morphogenesis and pathogenesis: numerous anti-fungal drugs rely on targeting either the cell wall or cell membrane, but the pipeline of available bioactives is limited. There is a clear and unmet need to identify novel targets and develop new classes of anti-fungal agents. This mini review focuses on fungal cell wall structure, composition and biosynthesis in Candida spp., including C. auris. In addition, an overview of current advances in the development of cell wall targeted therapies is considered.
vaccines, glycoproteins, inhibitors, chitin, fungal cell wall
Structure type: homopolymer
Location inside paper: Fig. 2, A
Trivial name: chitin
Compound class: O-polysaccharide, cell wall polysaccharide, glucan, polysaccharide, chitin
Contained glycoepitopes: IEDB_135813,IEDB_137340,IEDB_141807,IEDB_151531,IEDB_153212,IEDB_241099,IEDB_423114,IEDB_423150,SB_74,SB_85
Comments, role: review
NCBI Taxonomy refs (TaxIDs): 5476Reference(s) to other database(s): GTC:G97099AY, CCSD:
46067, CBank-STR:5851, GenDB:KF905651
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
report error