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ICD call error: XN31P does not exist

Taxonomic group: fungi / Ascomycota (Phylum: Ascomycota)
Associated disease: infection due to Candida albicans [ICD11: XN31P]

NCBI PubMed ID: 37520856
Publication DOI: 10.1016/j.tcsw.2023.100109
Journal NLM ID: 101728565
Publisher: Amsterdam: Elsevier
Correspondence: A. Ardá <aarda

cicbiogune.es>; J. Jiménez-Barbero <jjbarbero

cicbiogune.es>; N.E. Nifantiev <nen

ioc.ac.ru>
Institutions: Laboratory of Glycoconjugate Chemistry, N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia, CIC bioGUNE, Basque Research Technology Alliance, BRTA, 48160 Derio, Spain, Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter EX4 4QD, United Kingdom, IKERBASQUE, Basque Foundation for Science and Technology, Euskadi Plaza 5, 48009 Bilbao, Spain, Department of Organic & Inorganic Chemistry, Faculty of Science and Technology, University of the Basque Country, 48940 Leioa, Spain

The dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is an innate immune C-type lectin receptor that recognizes carbohydrate-based pathogen associated with molecular patterns of various bacteria, fungi, viruses and protozoa. Although a range of highly mannosylated glycoproteins have been shown to induce signaling via DC-SIGN, precise structure of the recognized oligosaccharide epitope is still unclear. Using the array of oligosaccharides related to selected fragments of main fungal antigenic polysaccharides we revealed a highly specific pentamannoside ligand of DC-SIGN, consisting of α-(1→2)-linked mannose chains with one inner α-(1→3)-linked unit. This structural motif is present in Candida albicans cell wall mannan and corresponds to its antigenic factors 4 and 13b. This epitope is not ubiquitous in other yeast species and may account for the species-specific nature of fungal recognition via DC-SIGN. The discovered highly specific oligosaccharide ligands of DC-SIGN are tractable tools for interdisciplinary investigations of mechanisms of fungal innate immunity and anti-Candida defense. Ligand- and receptor-based NMR data demonstrated the pentasaccharide-to-DC-SIGN interaction in solution and enabled the deciphering of the interaction topology.

DC-SIGN, glycoarray, Candida albicans mannan, NMR binding and conformational studies, oligomannoside ligand

Structure type: polymer chemical repeating unit
Location inside paper: Fig. 1
Trivial name: mannan
Compound class: cell wall polysaccharide
Contained glycoepitopes: IEDB_128161,IEDB_130701,IEDB_131173,IEDB_133966,IEDB_133967,IEDB_134618,IEDB_134620,IEDB_134621,IEDB_136104,IEDB_137485,IEDB_140116,IEDB_141111,IEDB_141793,IEDB_141795,IEDB_141828,IEDB_141829,IEDB_141830,IEDB_141831,IEDB_141832,IEDB_141833,IEDB_142357,IEDB_143632,IEDB_144983,IEDB_144994,IEDB_144995,IEDB_144996,IEDB_152206,IEDB_153220,IEDB_153756,IEDB_153762,IEDB_153763,IEDB_1539315,IEDB_164174,IEDB_164175,IEDB_164176,IEDB_164177,IEDB_164479,IEDB_164480,IEDB_173895,IEDB_174840,IEDB_2278480,IEDB_474450,IEDB_76920,IEDB_76933,IEDB_857732,IEDB_857735,IEDB_858578,IEDB_983930,SB_136,SB_191,SB_196,SB_197,SB_198,SB_44,SB_67,SB_72,SB_73

Methods: NMR, MD simulations, NOESY, conformational analysis, 1H STD NMR, glycoarray
3D data: model building for the DC-SIGN lectin and complexes

Related record ID(s): 41423
NCBI Taxonomy refs (TaxIDs): 5476
Show glycosyltransferases

There is only one chemically distinct structure:

*OC[C@H]1O[C@H](OC[C@H]2O[C@H](OC[C@H]3O[C@H](OC[C@H]4O[C@H](OC[C@H]5O[C@H](OC[C@H]6O[C@H](OC[C@H]7O[C@H](OC[C@H]8O[C@H](OC[C@H]9O[C@H](OC[C@H]%10O[C@H](OC[C@H]%11O[C@H](OC[C@H]%12O[C@H](OC[C@H]%13O[C@H](*)[C@@H](O[C@H]%14O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%14O[C@H]%14O[C@H](COP(=O)(O)O[C@H]%15O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%15O[C@@H]%15O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%15O[C@@H]%15O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%15O)[C@@H](O)[C@H](O)[C@@H]%14O[C@H]%14O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%14O)[C@@H](O)[C@@H]%13O)[C@@H](O[C@H]%13O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%13O[C@H]%13O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%13O[C@H]%13O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%13O[C@@H]%13O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%13O[C@@H]%13O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%13O[C@@H]%13O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%13O[C@@H]%13O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%13O)[C@@H](O)[C@@H]%12O)[C@@H](O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%12O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%12O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%12O[C@@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%12O[C@@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%12O[C@@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%12O)[C@@H](O)[C@@H]%11O)[C@@H](O[C@H]%11O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%11O[C@H]%11O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%11O[C@H]%11O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%11O[C@@H]%11O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%11O[C@@H]%11O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%11O)[C@@H](O)[C@@H]%10O)[C@@H](O[C@H]%10O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%10O[C@H]%10O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%10O[C@H]%10O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%10O[C@@H]%10O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%10O)[C@@H](O)[C@@H]9O)[C@@H](O[C@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]9O[C@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]9O[C@H]9O[C@H](CO[C@H]%10O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%10O)[C@@H](O)[C@H](O[C@H]%10O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%10O[C@H]%10O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%10O)[C@@H]9O)[C@@H](O)[C@@H]8O)[C@@H](O[C@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]8O[C@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]8O[C@H]8O[C@H](CO[C@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]9O)[C@@H](O)[C@H](O[C@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]9O)[C@@H]8O)[C@@H](O)[C@@H]7O)[C@@H](O[C@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]7O[C@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]7O[C@H]7O[C@H](CO)[C@@H](O)[C@H](O[C@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]8O[C@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]8O)[C@@H]7O)[C@@H](O)[C@@H]6O)[C@@H](O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]6O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]6O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O[C@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]7O)[C@@H]6O)[C@@H](O)[C@@H]5O)[C@@H](O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O)[C@@H](O)[C@@H]4O)[C@@H](O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)[C@@H](O)[C@@H]3O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H](O)[C@@H]1O

SVG MW SMILES 3D mol Ionize

Warning = sub-repeat ending at bDManp: variable unit count (0-2) was assumed to be 0