Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Associated disease: infection due to Aspergillus fumigatus [ICD11:
XN5Z7 
]
Publication DOI: 10.1080/13693780400029155Journal NLM ID: 9815835Publisher: Oxford: Oxford University Press
Correspondence: jplatge
pasteur.fr
Institutions: Le Reseau International des Instituts Pasteur (RIIP), Aspergillus Unit, 25 Rue Dr Roux, F-75724 Paris, France, The Institute for Genomic Research, Rockville, MD, USA
The cell wall of Aspergillus fumigatus is composed of a branched PI,3 glucan covalently bound to chitin, β-1,3, β-1,4 glucans, and galactomannan, that is embedded in an amorphous cement composed of α-1,3 glucan, galactomannan and polygalactosamin. The mycelial cell wall of A. fumigatus is very different from the yeast Saccharomyces cerevisiae cell wall, and in particular lacks 01,6 glucans and proteins covalently bound to cell wall polysaccharides. The differences in cell wall composition between the mould A. fumigatus and the yeast S. cerevisiae are also reflected at the genomic level where unique features have been identified in A. fumigatus. A single gene codes for the glucan synthase catalytic subumit; this finding has lead to the development of a RNAi methodology for the disruption of essential genes in A. fumigatus. In contrast to the glucan synthase, multiple genes have been found in the chitin synthase and the α-glucan synthase families; in spite of homologous sequences, each gene in each family have very different function. Similarly homologous mannosyltransferase genes are found in yeast and moulds but they lead to the synthesis of very different N-mannan structures. This chemo-genomic comparative analysis has also suggested that GPI-anchored proteins do not have a role of linker in the three dimensional organization of the fungal cell wall.
cell wall, mannan, glucan, GPI, chitin
Structure type: fragment of a bigger structure
Location inside paper: p.S16
Trivial name: a repeating mannose oligosaccharide unit
Compound class: cell wall polysaccharide, mannan
Contained glycoepitopes: IEDB_130701,IEDB_136104,IEDB_140116,IEDB_141793,IEDB_141795,IEDB_141829,IEDB_141830,IEDB_141832,IEDB_141833,IEDB_143632,IEDB_144983,IEDB_152206,IEDB_153220,IEDB_164480,IEDB_76933,IEDB_983930,SB_136,SB_191,SB_196,SB_198,SB_44,SB_67,SB_72
Comments, role: Review. Part of galactomannan which has a branched structure composed of a linear a mannan and short chains of b(1,5)-galactofuranose residues.
Related record ID(s): 41268, 42138, 42139, 42140
NCBI Taxonomy refs (TaxIDs): 746128Reference(s) to other database(s): GTC:G01019GW
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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