Taxonomic group: bacteria / Firmicutes
(Phylum: Firmicutes)
Associated disease: infection due to Streptococcus pneumoniae [ICD11:
XN3PW 
]
NCBI PubMed ID: 32679340Publication DOI: 10.1016/j.carres.2020.108045Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: pk.mandal
cdri.res.in
Institutions: Academy of Scientific and Innovative Research, New Delhi, India, Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow, 226031, India.Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow, 226031, India
Oligosaccharides play a very important role in biological system and structure-activity relationships that is why it has a lot of application to medicinal chemistry and development of polysaccharide conjugate vaccines. The stereoselective introduction of a glycosidic linkage presents the principal challenge for biological importance oligosaccharide synthesis. The main aim of this review is to described the importance of chiral auxiliary and neibhouring group participation for the stereoselective 1,2-cis glycosidic bonds formation and their application in complex oligosaccharide synthesis.Numerous 1,2-cis-linked oligosaccharides and glyconjugates are naturally found in the compounds of blood group, human milk, antigens of bacterial lipopolysaccharide etc.that predominantly increased it's importance in this field.
Oligosaccharides, glycosylation, stereoselective, 1, 2-Cis glycosidic bonds, Chiral auxiliary
Structure type: polymer chemical repeating unit
Location inside paper: Fig.1, S. pneumoniae serotype 6B
Trivial name: repeating unit of the capsular polysaccharide
Compound class: CPS, K-antigen
Contained glycoepitopes: IEDB_114703,IEDB_136105,IEDB_136906,IEDB_137472,IEDB_141794,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_151528,IEDB_153532,IEDB_153533,IEDB_153534,IEDB_153753,IEDB_158539,IEDB_190606,IEDB_225177,IEDB_591403,IEDB_885823,IEDB_983931,SB_192,SB_7
Comments, role: review
NCBI Taxonomy refs (TaxIDs): 1313Reference(s) to other database(s): GTC:G16389YP, GlycomeDB:
15851
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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