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Taxonomic group: fungi / Ascomycota (Phylum: Ascomycota)
Associated disease: infection due to Aspergillus fumigatus [ICD11: XN5Z7

]

NCBI PubMed ID: 19722017
Publication DOI: 10.1590/S0001-37652009000300012
Journal NLM ID: 7503280
Publisher: Academia Brasileira De Ciencias
Correspondence: Anita H. Straus <straus.bioq

epm.br>
Institutions: Setor de Imunoquímica de Glicoconjugados, Departamento de Bioquímica Ed. J.L. Prado, São Paulo, Brasil, Departamento de Microbiologia, Imunologia e Parasitologia, São Paulo, Brasil

Recently, glycosphingolipids have been attracting attention due to their role on biological systems as second messengers or modulators of signal transduction, affecting several events, which range from apoptosis to regulation of the cell cycle. In pathogenic fungi, glycolipids are expressed in two classes: neutral monohexosylceramides (glucosyl-or galactosylceramide) and acidic glycosylinositol phosphorylceramides (the latter class carries longer glycan chains). It is worth to mention that monohexosylceramides exhibit significant structural differences in their lipid moieties compared to their mammalian counterparts, whereas the glycosylinositol phosphorylceramides exhibit remarkable structural differences in their carbohydrate moieties in comparison to mammal glycosphingolipids counterpart. We observed that glycosylinositol phosphorylceramides are capable of promoting immune response in infected humans. In addition, inhibiting fungal glycosphingolipid biosynthetic pathways leads to an inhibition of colony formation, spore germination, cell cycle, dimorphism and hyphal growth. Other pathogens, such as trypanosomatids, also present unique glycolipids, which may have an important role for the parasite development and/or disease establishment. Regarding host-pathogen interaction, cell membrane rafts, which are enriched in sphingolipids and sterols, participate in parasite/fungal infection. In this review, it is discussed the different biological roles of (glyco) (sphingo)lipids of pathogenic/opportunistic fungi and trypanosomatids.

glycosphingolipids, leishmania, glycosylinositol phosphorylceramides, inositol phosphorylceramide, membrane rafts, pathogenic fungi

Structure type: oligomer
Location inside paper: p.479, table II, Af-4
Compound class: glycosphingolipid
Contained glycoepitopes: IEDB_130701,IEDB_136095,IEDB_136104,IEDB_137472,IEDB_1394182,IEDB_140116,IEDB_143632,IEDB_144983,IEDB_152206,IEDB_164174,IEDB_190606,IEDB_983930,SB_136,SB_196,SB_197,SB_44,SB_67,SB_72

Comments, role: review; acidic glycosphingolipids

Related record ID(s): 41731, 41948, 41949, 41950, 41952, 42158
NCBI Taxonomy refs (TaxIDs): 746128
Show glycosyltransferases

There are 16 chemically distinct structures. Please, select:

CCCCCCCCCCCCCCCCCCCCCCC(O)C(=O)N[C@@H](COP(=O)(O)O[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@@H]1O[C@H]1O[C@H](CO[C@@H]2O[C@@H]([C@H](O)CO)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]2O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]2O)[C@@H]1O)[C@H](O)[C@H](O)CCCCCCCCCCCCCC

SVG MW SMILES 3D mol Ionize