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Taxonomic group: fungi / Ascomycota (Phylum: Ascomycota)
Associated disease: infection due to Aspergillus fumigatus [ICD11: XN5Z7

]

NCBI PubMed ID: 17587671
Publication DOI: 10.1271/bbb.70080
Journal NLM ID: 9205717
Publisher: Japan Society for Bioscience, Biotechnology, and Agrochemistry
Correspondence: m_goto

agr.kyushu-u.ac.jp
Institutions: Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Japan

Protein glycosylation is essential for eukaryotic cells from yeasts to humans. When compared to N-glycosylation, O-glycosylation is variable in sugar components and the mode of linkages connecting the sugars. In fungi, secretory proteins are commonly mannosylated by protein O-mannosyltransferase (PMT) in the endoplasmic reticulum, and subsequently glycosylated by several glycosyltransferases in the Golgi apparatus to form glycoproteins with diverse O-glycan structures. Protein O-glycosylation has roles in modulating the function of secretory proteins by enhancing the stability and solubility of the proteins, by affording protection from protease degradation, and by acting as a sorting determinant in yeasts. In filamentous fungi, protein O-glycosylation contributes to proper maintenance of fungal morphology, hyphal development, and differentiation. This review describes recent studies of the structure and function of protein O-glycosylation in industrially and medically important fungi.

O-glycosylation, Aspergillus, protein O-mannosyltransferase

Structure type: oligomer
Location inside paper: p.1418
Aglycon: (->3) Ser/Thr-peptide
Compound class: glycoprotein, O-glycan
Contained glycoepitopes: IEDB_130701,IEDB_136095,IEDB_137472,IEDB_137485,IEDB_1394182,IEDB_144983,IEDB_147453,IEDB_149137,IEDB_152206,IEDB_190606,IEDB_885812,IEDB_983930,SB_44,SB_67,SB_72

Comments, role: review

Related record ID(s): 41804, 42023, 42024, 42025, 42026, 42027, 42028, 42029, 42030, 42031, 42204, 42205, 42206, 42207, 42208, 42209, 42210, 42211, 42212, 42213
NCBI Taxonomy refs (TaxIDs): 746128
Reference(s) to other database(s): GTC:G75560VA
Show glycosyltransferases

There are 64 chemically distinct structures. Please, select:

OC[C@@H](O)[C@@H]1O[C@@H](O[C@H](CO)[C@@H]2O[C@@H](O[C@H](CO)[C@@H]3O[C@@H](O[C@H](CO)[C@@H]4O[C@@H](O[C@H](CO)[C@@H]5O[C@@H](OC[C@H]6OC(O)[C@@H](O)[C@@H](O)[C@@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O

SVG MW SMILES 3D mol Ionize