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Taxonomic group: fungi / Basidiomycota (Phylum: Basidiomycota)
Associated disease: infection due to Cryptococcus neoformans [ICD11: XN3EH

]; infection due to Cryptococcus gattii [ICD11: XN0LE

]

NCBI PubMed ID: 17114598
Publication DOI: 10.1016/j.tim.2006.09.003
Journal NLM ID: 9310916
Publisher: Cambridge: Elsevier Trends Journals
Correspondence: Casadevall A <casadeva

aecom.yu.edu>
Institutions: Department of Medicine, Division of Infectious Disease, Albert Einstein College of Medicine, Bronx, NY, USA, Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA, Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain, Northeast Biodefense Center, Department of Epidemiology, Columbia University, New York, NY, USA

Cryptococcus neoformans is a soil-dwelling fungus that causes life-threatening illness in immunocompromised individuals and latently infects many healthy individuals. C. neoformans, unlike other human pathogenic fungi, is surrounded by a polysaccharide capsule that is essential for survival and enables C. neoformans to thwart the mammalian immune system. The capsule is a dynamic structure that undergoes changes in size and rearranges during budding. Here, the latest information and unresolved questions regarding capsule synthesis, structure, assembly, growth and rearrangements are discussed along with the concept that self-assembly is important in capsular dynamics.

virulence, polysaccharide capsule, Cryptococcus neoformans, Glucuronoxylomannan

Structure type: suggested polymer biological repeating unit
Location inside paper: p. 498, Fig. 1
Trivial name: glucuronoxylomannan (GXM)
Compound class: CPS
Contained glycoepitopes: IEDB_114701,IEDB_115136,IEDB_115576,IEDB_130701,IEDB_140116,IEDB_140630,IEDB_144983,IEDB_145668,IEDB_152206,IEDB_164174,IEDB_167188,IEDB_174332,IEDB_2270799,IEDB_423153,IEDB_76933,IEDB_983930,SB_197,SB_44,SB_67,SB_72

Comments, role: review; D configurations of mannose residues were assumed by CSDB staff

Related record ID(s): 41819, 42223, 42225, 43556
NCBI Taxonomy refs (TaxIDs): 37769
Reference(s) to other database(s): GTC:G58881RT
Show glycosyltransferases

There are 32 chemically distinct structures. Please, select:

*O[C@H]1[C@H](O[C@@H]2OC[C@@H](O)[C@H](O)[C@H]2O)[C@@H](CO)O[C@H](O[C@@H]2[C@H](O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O[C@@H]3[C@H](O[C@@H]4OC[C@@H](O)[C@H](O)[C@H]4O)[C@@H](*)O[C@H](CO)[C@H]3O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)O[C@H](CO)[C@H]2O)[C@H]1O[C@@H]1O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]1O

SVG MW SMILES 3D mol Ionize