Taxonomic group: fungi / Ascomycota, Basidiomycota
(Phylum: Ascomycota, Basidiomycota)
Organ / tissue: fruiting body
Publication DOI: 10.1016/j.tifs.2006.07.013Journal NLM ID: 9426004Publisher: Cambridge, UK: Elsevier Trends Journals
Correspondence: SW Cui <cuis
agr.gc.ca>
Institutions: Food research program, Agriculture and Agri-Food Canada, Guelph, Ontario, Canada, The Department of Biology, The Chinese University of Hong Kong, Shatin, China
Mushrooms have been valued as edible and medicinal resources, and antitumor substances have been identified in many mushroom species. Polysaccharides are the best known and most potent mushroom-derived substances with antitumor and immunomodulating properties. Although the isolation process, structural characterization and antitumor activity of mushroom polysaccharides have been extensively investigated in the past three decades, the relationship between the antitumor activity and the chemical composition as well as the high order structure of their active components is still not well established. These studies are still in progress in many laboratories, and the role of polysaccharides as antitumor agent is especially under intense debate. The purpose of the present review is to summarize the available information, and to reflect the current status of this research area with a view for future direction.
structure, biological activity, mushrooms, antitumor polysaccharides
Structure type: homopolymer
Location inside paper: p.8, table 2
Trivial name: glucan, β-1,3-glucan, curdlan, curdlan-type polysaccharide 13140, paramylon, curdlan, laminarin, β-glucan, curdlan, β-(1,3)-glucan, β-(1,3)-glucan, curdlan, curdlan, β-1,3-glucan, paramylon, reserve polysaccharide, b-glucan, β-1,3-D-glucan, laminaran, botryosphaeran, laminaran type β-D-glucan, latiglucan I, pachymaran, Curdlan, zymosan A, β-glucan, curdlan, laminarin, zymosan, zymosan, glucan particles, zymosan, β-(1-3)-glucan, β-(1,3)-glucan, β-(1,3)glucan, pachymaran, D-glucan (DPn)540, pachyman, laminaran, curdlan, zymosan, zymosan, β-(1,3)-glucan, zymosan A, zymosan, β-1,3-glucan, curdlan, β-1,3-glucan, curdlan, β-1,3-glucan, curdlan, pachyman, β-(1,3)-glucan, curdlan, callose, a water-insoluble β-(1→3)-glucan, fermentum β-polysaccharide, water-insoluble glucan, alkali-soluble β-glucan (PeA3), alkali-soluble polysaccharide (PCAP), callose, laminarin
Compound class: EPS, O-polysaccharide, cell wall polysaccharide, lipophosphoglycan, glycoprotein, LPG, glucan, polysaccharide, glycoside, β-glucan, β3-glucan, cell wall glucan
Contained glycoepitopes: IEDB_1397514,IEDB_142488,IEDB_146664,IEDB_153543,IEDB_158555,IEDB_161166,IEDB_2278476,IEDB_2278477,IEDB_558869,IEDB_857743,IEDB_983931,SB_192
Methods: methylation, NMR, composition analysis, HPLC
Biological activity: hyperglycemia, immunomodulating, antitumor, antioxidative, anti-decrepitude activity
Comments, role: review
Related record ID(s): 41845, 42237, 42238
NCBI Taxonomy refs (TaxIDs): 29892,
64660Reference(s) to other database(s): GTC:G51056AN, GlycomeDB:
157, CCSD:
50049, CBank-STR:4225, CA-RN: 51052-65-4, GenDB:FJ3380871.1
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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