Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Organ / tissue: cell wallAssociated disease: Crohn disease [ICD11:
DD70 
]
NCBI PubMed ID: 26440374Publication DOI: 10.1080/19490976.2015.1091913Journal NLM ID: 101495343Publisher: Philadelphia, PA: Taylor & Francis
Correspondence: Abbott DW <wade.abbott
agr.gc.ca>, Martens EC <emartens
umich.edu>, Gilbert HJ <harry.gilbert
ncl.ac.uk>
Institutions: Lethbridge Research Centre, Agriculture and Agri-Food Canada, Lethbridge Alberta, Canada, Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, USA, Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle, UK
The complex carbohydrates accessible to the distal gut microbiota (DGM) are key drivers in determining the structure of this ecosystem. Typically, plant cell wall polysaccharides and recalcitrant starch (i.e. dietary fiber), in addition to host glycans are considered the primary nutrients for the DGM; however, we recently demonstrated that α-mannans, highly branched polysaccharides that decorate the surface of yeast, are also nutrients for several members of Bacteroides spp. This relationship suggests that the advent of yeast in contemporary food technologies and the colonization of the intestine by endogenous fungi have roles in microbiome structure and function. Here we discuss the process of yeast mannan metabolism, and the interparagraph between various sources of intestinal fungi and their roles in recognition by the host innate immune system.
polysaccharide, symbiosis, evolution, mannooligosaccharide, fungal cell wall, carbohydrate active enzyme, catabolism, distal gut microbiota, yeast mannan
Structure type: fragment of a bigger structure
Location inside paper: Fig.1, p. 338, paragraph 1
Compound class: N-glycan, mannan
Contained glycoepitopes: IEDB_130701,IEDB_136104,IEDB_140116,IEDB_141111,IEDB_141830,IEDB_143632,IEDB_144983,IEDB_152206,IEDB_164174,IEDB_164175,IEDB_164176,IEDB_174840,IEDB_76933,IEDB_983930,SB_136,SB_196,SB_197,SB_44,SB_67,SB_72
Enzymes that release or process the structure: Van1p
Comments, role: side chain of α-1,6-mannan backbone
Related record ID(s): 42305, 42306, 42307, 42308
NCBI Taxonomy refs (TaxIDs): 4932Reference(s) to other database(s): GTC:G29966LR
Show glycosyltransferases
There is only one chemically distinct structure:
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