Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
Organ / tissue: cell wall
Publication DOI: 10.1002/9781118930458.ch20Publisher: John Wiley & Sons
Editors: Bagchi D, Swaroop A, Bagchi M
Institutions: Department of Microbiology, Maulana Azad College, Kolkata, India, Drug Development, Diagnostics and Biotechnology, CSIR-Indian Institute of Chemical Biology, Kolkata, India, Department of Zoology, West Bengal State University, India
Consumption of edible mushrooms has been practiced since ages to promote human health and as traditional remedies for multiple human ailments. The excellent nutritional quality of these organisms collectively called as filamentous fungi for their filament like hyphal extension, owes to a high protein, low fat and cholesterol free profile. Over the last decade, a diverse repertoire of protein-glycan conjugates isolated from these organisms has been attributed with immunomodulatory, anticancer, and other therapeutic activities. An integrated use of conventional chemical analyses, improved separation technologies, and new generation high-throughput proteomic approaches has revealed features in these complex biomolecules unknown elsewhere amongst the eukaryotes. However, due to some serious technological bottlenecks, a comprehensive structure-function delineation of the fungal glycoproteome has eluded the scientists. If we can prevail over these constraints and dig deep into this unique niche of the fungal kingdom, the quest for new generation nutraceuticals and therapeutics will get headway.
glycoproteins, mushrooms, Glycoproteomics, filamentous fungi, polysaccharopeptide complexes, nutraceuticals, therapeutic enzymes
Structure type: homopolymer
Location inside paper: table 20.4
Trivial name: pustulan, β-1,6-glucan, β-1,6-D-glucan, β(1-6)-D-glucan, β-(1,6)-glucan, lasiodiplodan, pustulan, β-(1,6)-glucan, lasiodiplodan, β-(1,6)-glucan, β-(1,6)-glucan, lasiodiplodan, pustulan, β-1,6-glucan, β-(1,6)-glucan, pustulan, β-(1→6)-glucan PCPS, water-soluble glucan (PS-I)
Compound class: EPS, O-polysaccharide, cell wall polysaccharide, glycoprotein, glucan, polysaccharide, cell wall glucoprotein
Contained glycoepitopes: IEDB_135614,IEDB_141806,IEDB_142488,IEDB_146664,IEDB_241101,IEDB_983931,SB_192
Biological activity: immunomodulator activity in pre-clinical animal models(cancer)
Comments, role: review
Related record ID(s): 42488, 42489, 42490, 42491, 42492, 42495, 42498, 42500, 48501, 48502
NCBI Taxonomy refs (TaxIDs): 1929756,
64660Reference(s) to other database(s): GTC:G26777BZ, GlycomeDB:
863, CCSD:
50854, CBank-STR:4234
Show glycosyltransferases
There is only one chemically distinct structure:
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(previously named: Armillaria tabescens; later renamed to: Desarmillaria tabescens)