Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Organ / tissue: cell wall,
biofirm matrix
NCBI PubMed ID: 27129222Publication DOI: 10.1074/jbc.R116.720995Journal NLM ID: 2985121RPublisher: Baltimore, MD: American Society for Biochemistry and Molecular Biology
Correspondence: Sheppard DC <don.sheppard
mcgill.ca>; Howell PL <howell
sickkids.ca>
Institutions: Departments of Medicine, Microbiology and Immunology and Infectious Diseases Research Institute of the McGill University Health Centre, McGill University, Montréal, Québec, Canada, Immunity in Global Health Program, Research Institute of the McGill University Health Centre, McGill University, Montréal, Québec, Canada, Program in Molecular Structure & Function, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
Exopolysaccharides play an important structural and functional role in the development and maintenance of microbial biofilms. Although the majority of research to date has focused on the exopolysaccharide systems of biofilm-forming bacteria, recent studies have demonstrated that medically relevant fungi such as Candida albicans and Aspergillus fumigatus also form biofilms during infection. These fungal biofilms share many similarities with those of bacteria, including the presence of secreted exopolysaccharides as core components of the extracellular matrix. This review will highlight our current understanding of fungal biofilm exopolysaccharides, as well as the parallels that can be drawn with those of their bacterial counterparts.
polysaccharide, exopolysaccharide, Bacterial Adhesion, Biofilm, Extracellular matrix, carbohydrate biosynthesis
Structure type: homopolymer
Location inside paper: fig. 2 (β1-6 glucans)
Trivial name: pustulan, β-1,6-glucan, β-1,6-D-glucan, β(1-6)-D-glucan, β-(1,6)-glucan, lasiodiplodan, pustulan, β-(1,6)-glucan, lasiodiplodan, β-(1,6)-glucan, β-(1,6)-glucan, lasiodiplodan, pustulan, β-1,6-glucan, β-(1,6)-glucan, pustulan, β-(1→6)-glucan PCPS, water-soluble glucan (PS-I)
Compound class: EPS, O-polysaccharide, cell wall polysaccharide, glycoprotein, glucan, polysaccharide, cell wall glucoprotein
Contained glycoepitopes: IEDB_135614,IEDB_141806,IEDB_142488,IEDB_146664,IEDB_241101,IEDB_983931,SB_192
Synthetic data: biosynthesis
Comments, role: review
Related record ID(s): 42652, 42654
NCBI Taxonomy refs (TaxIDs): 5476Reference(s) to other database(s): GTC:G26777BZ, GlycomeDB:
863, CCSD:
50854, CBank-STR:4234
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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(previously named: Saccharomyces albicans, Dematium albicans, Monilia albicans, Parasaccharomyces albicans, Myceloblastanon albicans, Mycotorula albicans, Syringospora albicans, Procandida albicans)