CSDB: Search results

Cryptococcus neoformans

(previously named: Blastomyces neoformans, Debaryomyces neoformans, Lipomyces neoformans, Saccharomyces neoformans, Torula neoformans, Torulopsis neoformans, Filobasidiella neoformans)
(NCBI TaxID 5207, species name lookup)

Taxonomic group: fungi / Basidiomycota (Phylum: Basidiomycota)
Associated disease: infection due to Cryptococcus neoformans [ICD11: XN3EH

]

NCBI PubMed ID: 28876853
Publication DOI: 10.1101/glycobiology.3e.023
WWW link: https://www.ncbi.nlm.nih.gov/books/NBK453054/
Publisher: Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press
Editors: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger RH
Institutions: Complex Carbohydrate Research Center, University of Georgia, Athens, USA, Laboratory of Immunoglycobiology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan, Distinguished Professor of Medicine and Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, USA, National Center for Functional Glycomics, Harvard Medical School, Cambridge, USA, Glycobiology Research and Training Center, University of California, San Diego, USA, Albert Einstein College of Medicine, New York, NY, USA, Johns Hopkins University, Baltimore, USA, ETH Zürich, Zürich, Switzerland, Macquarie University and Institute for Glycomics, Griffith University, Sydney, Australia, University of Georgia, Athens, Georgia, USA, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

Fungi are a fascinating group of predominantly multicellular organisms. Fungal species, such as Saccharomyces cerevisiae, have been instrumental in defining the fundamental processes of glycosylation, but their glycobiology is significantly different from animal or plant systems. This chapter describes the glycan structures that compose the fungal cell wall, offers some insights into novel glycobiology revealed through studying fungal systems, addresses the use of fungi as experimental and synthetic systems, and delineates the relationships of several important glycoconjugates to fungal biology and pathogenesis.

Structure type: polymer chemical repeating unit
Location inside paper: figure 23.7, galactoxylomannan (GalXM)
Compound class: galactoxylomannan
Contained glycoepitopes: IEDB_114701,IEDB_130701,IEDB_134624,IEDB_136044,IEDB_136906,IEDB_137472,IEDB_141794,IEDB_144983,IEDB_145668,IEDB_151528,IEDB_152206,IEDB_164174,IEDB_167188,IEDB_174332,IEDB_190606,IEDB_983930,SB_163,SB_165,SB_166,SB_187,SB_195,SB_197,SB_44,SB_67,SB_7,SB_72,SB_88

Comments, role: Cryptococcus neoformans galactoxylomannan (GalXM); absolute D-confugurations and pyranose ring sizes were assumed by CSDB staff based on indication of L-configuration or furanose-form for individual residues in the figures

Related record ID(s): 42943, 42944, 42945, 42946, 42947, 42948, 42949, 42950, 42951, 42952, 42953, 42954, 42955, 42956, 42957, 42958, 42959, 42960, 42961, 42962, 42964, 42965, 42966, 42967, 42968, 42969, 42970, 42971, 42972, 42973, 42974, 42975, 42976, 42977, 42978, 42979, 42980, 42981, 42982, 42983, 42984, 42985, 42986, 42987, 42988
NCBI Taxonomy refs (TaxIDs): 5207
Reference(s) to other database(s): GTC:G10258DN
Show glycosyltransferases

There is only one chemically distinct structure:

*OC[C@H]1O[C@H](OC[C@H]2O[C@H](OC[C@H]3O[C@H](OC[C@H]4O[C@H](*)[C@H](O)[C@@H](O[C@@H]5O[C@H](CO)[C@H](O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O[C@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]7O)[C@@H]6O)[C@H](O)[C@H]5O)[C@H]4O)[C@H](O)[C@@H](O)[C@H]3O)[C@H](O)[C@@H](O[C@@H]3O[C@H](CO)[C@H](O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O[C@@H]6OC[C@@H](O)[C@H](O)[C@H]6O)[C@@H]5O)[C@@H]4O[C@@H]4OC[C@@H](O)[C@H](O)[C@H]4O)[C@H](O[C@@H]4OC[C@@H](O)[C@H](O)[C@H]4O)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O

SVG MW SMILES 3D mol Ionize