Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Organ / tissue: myceliumAssociated disease: infection due to Aspergillus fumigatus [ICD11:
XN5Z7 
]
NCBI PubMed ID: 28652019Publication DOI: 10.1016/j.biochi.2017.06.012Journal NLM ID: 1264604Publisher: Paris: Editions Scientifiques Elsevier
Correspondence: thierry.fontaine
pasteur.fr
Institutions: Unité des Aspergillus, Institut Pasteur, Paris, France
Sphingolipids (SPLs) are key components of the plasma membrane in yeast and filamentous fungi. These molecules are involved in a number of cellular processes, and particularly, SGLs are essential components of the highly polarized fungal growth where they are required for the formation of the polarisome organization at the hyphal apex. Aspergillus fumigatus, a human fungal pathogen, produce SGLs that are discriminated into neutral cerebrosides, glycosylinositolphosphoceramides (GIPCs) and glycosylphosphatidylinositol (GPI) anchors. In addition to complex hydrophilic head groups of GIPCs, A. fumigatus is, to date, the sole fungus that produces a GPI-anchored polysaccharide. These SPLs follow three different biosynthetic pathways. Genetics blockage leading to the inhibition of any SPL biosynthesis or to the alteration of the structure of SPL induces growth and virulence defects. The complete lipid moiety of SPLs is essential for the lipid microdomain organization and their biosynthetic pathways are potential antifungal targets but remains understudied.
Aspergillus fumigatus, GPI, glucosylceramide, GIPC
Structure type: oligomer
Location inside paper: Table 1(9)
Compound class: glycosphingolipid, glycoinositolphosphoryl ceramide (GIPC)
Contained glycoepitopes: IEDB_115009,IEDB_116046,IEDB_130701,IEDB_136095,IEDB_137472,IEDB_140624,IEDB_144983,IEDB_152206,IEDB_164174,IEDB_190606,IEDB_983930,SB_197,SB_44,SB_67,SB_72
Related record ID(s): 43091, 43092, 43093, 43094, 43095, 43096, 43097, 43098, 43099, 43100, 43101, 43103, 43104, 43105
NCBI Taxonomy refs (TaxIDs): 746128
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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(previously named: Sartorya fumigata, Aspergillus fumigates; later renamed to: Neosartorya fumigata)