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Taxonomic group: fungi / Ascomycota (Phylum: Ascomycota)
Associated disease: infection due to Aspergillus fumigatus [ICD11: XN5Z7

]

NCBI PubMed ID: 21240441
Publication DOI: 10.1039/c0np00018c
Journal NLM ID: 8502408
Publisher: London: Royal Society of Chemistry
Correspondence: paolo.gualtieri

pi.ibf.cnr.it
Institutions: Istituto di Biofisica, Pisa, Italy

β-Glucans is the common name given to a group of chemically heterogeneous polysaccharides. They are long- or short-chain polymers of (1→3)-β-linked glucose moieties which may be branched, with the branching chains linked to the backbone by a (1→6)-β linkage. β-(1→3)-Glucans are widely distributed in bacteria, algae, fungi and plants, where they are involved in cell wall structure and other biological function. β-Glucans have been shown to provide a remarkable range of health benefits, and are especially important against the two most common conventional causes of death in industrialized countries, i.e. cardiovascular diseases (where they promote healthy cholesterol and blood glucose levels) and cancer (where they enhance immune system functions). This Highlight provides a comprehensive and up-to-date commentary on β-glucans, their chemistry, physico-chemistry, functional role in immunological responses, and possible applications as therapeutic tools. In addition, we discuss the mechanism behind their health benefits, which are not yet fully understood.

polysaccharides, β-Glucans, beta-glucans

Structure type: structural motif or average structure ; 190000-200000
Location inside paper: fig. 1f, Table 1
Compound class: glucan
Contained glycoepitopes: IEDB_135614,IEDB_1397514,IEDB_141806,IEDB_142488,IEDB_146664,IEDB_153543,IEDB_158555,IEDB_161166,IEDB_161167,IEDB_2278476,IEDB_2278477,IEDB_241101,IEDB_558867,IEDB_558869,IEDB_857743,IEDB_983931,SB_192

Comments, role: Saccharomyces cerevisiae glucan

Related record ID(s): 111144, 112939, 140142, 140209
NCBI Taxonomy refs (TaxIDs): 4932, 4896, 746128, 5476
Reference(s) to other database(s): GTC:G04765KG
Show glycosyltransferases

There is only one chemically distinct structure:

*O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H](O[C@@H]4[C@@H](O)[C@H](O[C@@H]5[C@@H](O)[C@H](*)O[C@H](CO[C@@H]6O[C@H](CO[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O[C@@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@H]9O)[C@H]8O)[C@H]7O)[C@@H](O)[C@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@H]7O)[C@H]6O)[C@H]5O)O[C@H](CO)[C@H]4O)O[C@H](CO)[C@H]3O)O[C@H](CO)[C@H]2O)[C@@H]1O

SVG MW SMILES 3D mol Ionize