Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
Organ / tissue: capsuleAssociated disease: infection due to Cryptococcus neoformans [ICD11:
XN3EH 
];
infection due to Cryptococcus gattii [ICD11:
XN0LE ]
NCBI PubMed ID: 21889889Publication DOI: 10.1016/j.sbi.2011.08.006Journal NLM ID: 9107784Publisher: Elsevier
Correspondence: doering
borcim.wustl.edu
Institutions: Department of Molecular Microbiology, Washington University Medical School, St. Louis, USA
Cryptococcus neoformans, a basidiomycete yeast and opportunistic pathogen, expends significant biosynthetic effort on construction of a polysaccharide capsule with a radius that may be many times that of the cell. Beyond posing a stimulating challenge in terms of defining biosynthetic pathways, the capsule is required for this yeast to cause fatal disease. This combination has focused the attention of researchers on this system. Here we briefly review two aspects of the rapidly advancing field of capsule synthesis: the extensive variation that occurs in capsule polymers and the regulation of capsule biosynthesis.
cryptococcal capsule synthesis
Structure type: suggested polymer biological repeating unit
Location inside paper: fig.2, M4, GXM
Trivial name: glucuronoxylomannan (GXM)
Compound class: CPS, EPS, O-polysaccharide, O-antigen, cell wall polysaccharide, polysaccharide, glucuronoxylomannan, capsule polysaccharide
Contained glycoepitopes: IEDB_114701,IEDB_115136,IEDB_115576,IEDB_130701,IEDB_140116,IEDB_140630,IEDB_144983,IEDB_145668,IEDB_152206,IEDB_164174,IEDB_167188,IEDB_174332,IEDB_2270799,IEDB_423153,IEDB_76933,IEDB_983930,SB_197,SB_44,SB_67,SB_72
Comments, role: SO from Clin Diagn Lab Immunol 1998,5:146-159 and ID 43809
Related record ID(s): 43502, 43503, 43504, 43506, 43507, 43508, 43556, 43809
NCBI Taxonomy refs (TaxIDs): 37769Reference(s) to other database(s): GTC:G39597XD
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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(later renamed to: Cryptococcus gattii VGI C)