Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
NCBI PubMed ID: 9368039Publication DOI: 10.1074/jbc.272.47.29704Journal NLM ID: 2985121RPublisher: Baltimore, MD: American Society for Biochemistry and Molecular Biology
Institutions: Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, USA
The Saccharomyces cerevisiae SCS7 and SUR2 genes are members of a gene family that encodes enzymes that desaturate or hydroxylate lipids. Sur2p is required for the hydroxylation of C-4 of the sphingoid moiety of ceramide, and Scs7p is required for the hydroxylation of the very long chain fatty acid. Neither SCS7 nor SUR2 are essential for growth, and lack of the Scs7p- or Sur2p-dependent hydroxylation does not prevent the synthesis of mannosyldiinositolphosphorylceramide, the mature sphingolipid found in yeast. Deletion of either gene suppresses the Ca2+-sensitive phenotype of csg2Delta mutants, which arises from overaccumulation of inositolphosphorylceramide due to a defect in sphingolipid mannosylation. Characterization of scs7 and sur2 mutants is expected to provide insight into the function of ceramide hydroxylation.
ceramide, hydroxylation, desaturation
Structure type: monomer
Location inside paper: fig.1, MIPC-C
Trivial name: sphingolipid
Compound class: glycolipid, ceramide
Contained glycoepitopes: IEDB_137485,IEDB_144983,IEDB_152206,IEDB_983930,SB_44,SB_72
Methods: DNA techniques, TLC, methanolysis, alkaline hydrolysis, extraction, cell growth
Related record ID(s): 43536, 43537, 43538, 43540
NCBI Taxonomy refs (TaxIDs): 4932
Show glycosyltransferases
There is only one chemically distinct structure:
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