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Taxonomic group: fungi / Basidiomycota (Phylum: Basidiomycota)
Host organism: Homo sapiens
Organ / tissue: capsule
Associated disease: cryptococcosis [ICD11: 1F27

, ICD11: XN0LE

, ICD11: XN3EH

]; infection due to Cryptococcus neoformans [ICD11: XN3EH

]; infection due to Cryptococcus gattii [ICD11: XN0LE

]

NCBI PubMed ID: 21886639
Publication DOI: 10.3389/fmicb.2011.00171
Journal NLM ID: 101548977
Publisher: Lausanne: Frontiers Research Foundation
Correspondence: Rodrigues ML <marcio

micro.ufrj.br>
Institutions: Laboratório de Estudos Integrados em Bioquímica Microbiana, Instituto de Microbiologia Professor Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, USA, Department of Medicine, Albert Einstein College of Medicine, Bronx, USA

Studies on structure and function of polysaccharides in biological systems classically involve sequence and compositional analyses, anomeric configuration, type of glycosidic linkage, and presence of substituents. Recent studies, however, indicates that other structural parameters, so far little explored, can directly influence the biological activity of microbial polysaccharides. Among these parameters, we highlight the molecular dimensions of Cryptococcus neoformans polysaccharides, which appear to be inversely correlated with their immunobiological activity. These recent observations raise new concepts about the structure and function of polysaccharides, which stimulates the design of new experimental approaches and suggests previously unknown applications.

polysaccharides, immunity, Cryptococcus neoformans, fungal pathogens, structure and function of polysaccharides

Structure type: suggested polymer biological repeating unit
Location inside paper: GXM, p.2
Compound class: glucuronoxylomannan
Contained glycoepitopes: IEDB_114701,IEDB_115136,IEDB_115576,IEDB_130701,IEDB_140116,IEDB_140630,IEDB_144983,IEDB_145668,IEDB_152206,IEDB_164174,IEDB_167188,IEDB_174332,IEDB_2270799,IEDB_423153,IEDB_76933,IEDB_983930,SB_197,SB_44,SB_67,SB_72

Comments, role: The parallel between capacity to induce of cellular responses and GXM molecular diameter was established. As one of them increases, the second decreases, and vice versa. Сhemical repeating unit frame was shifted in annotation for compatibility with structures elucidated by MS [Eukaryotic Cell 2007, 6: 1464-1473]

Related record ID(s): 73, 9355, 40516, 40737, 40817, 41247, 42131, 42201, 42224, 43505, 136942, 148632
NCBI Taxonomy refs (TaxIDs): 178876, 37769, 40410
Reference(s) to other database(s): GTC:G80604VY
Show glycosyltransferases

There are 2 chemically distinct structures. Please, select:

*O[C@@H]1[C@H](O[C@@H]2O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O[C@H]2[C@H](O)[C@@H](CO)O[C@H](O[C@@H]3[C@H](O[C@@H]4OC[C@@H](O)[C@H](O)[C@H]4O)[C@@H](*)O[C@H](CO)[C@H]3O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)[C@H]2O[C@@H]2OC[C@@H](O)[C@H](O)[C@H]2O)O[C@H](CO)[C@H]1O[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O

SVG MW SMILES 3D mol Ionize