Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Organ / tissue: cell wall
The structure was elucidated in this paperNCBI PubMed ID: 21254968Publication DOI: 10.3109/13693786.2010.551425Journal NLM ID: 9815835Publisher: Oxford: Oxford University Press
Correspondence: Gow NA <n.gow
abdn.ac.uk>
Institutions: The Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
The cell wall of the opportunistic human fungal pathogen, Candida albicans is a complex, layered network of rigid structural polysaccharides composed of β-glucans and chitin that is covered with a fibrillar matrix of highly glycosylated mannoproteins. Polymorphonuclear cells (PMNs, neutrophils) are the most prevalent circulating phagocytic leukocyte in peripheral blood and they are pivotal in the clearance of invading fungal cells from tissues. The importance of cell-wall mannans for the recognition and uptake of C. albicans by human PMNs was therefore investigated. N- and O-glycosylation-deficient mutants were attenuated in binding and phagocytosis by PMNs and this was associated with reduced killing of C. albicans yeast cells. No differences were found in the production of the respiratory burst enzyme myeloperoxidase (MPO) and the neutrophil chemokine IL-8 in PMNs exposed to control and glycosylation-deficient C. albicans strains. Thus, the significant decrease in killing of glycan-deficient C. albicans strains by PMNs is a consequence of a marked reduction in phagocytosis rather than changes in the release of inflammatory mediators by PMNs.
glycosylation, innate immunity, C. albicans, PMN
Structure type: oligomer
Location inside paper: fig. 1
Aglycon: (->3) L-Thr/L-Ser (protein)
Compound class: O-glycan
Contained glycoepitopes: IEDB_130701,IEDB_136104,IEDB_143632,IEDB_144983,IEDB_152206,IEDB_983930,SB_136,SB_196,SB_44,SB_67,SB_72
Methods: DNA techniques, flow cytometry analysis, FACS assay
Comments, role: This O-glycan produced by the pmr1Δ mutant.
Related record ID(s): 43618, 43619, 43631, 43632, 43634, 43635, 43636
NCBI Taxonomy refs (TaxIDs): 5476Reference(s) to other database(s): GTC:G53402KW
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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