Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Organ / tissue: Life stage: yeast phase,
myceliumAssociated disease: paracoccidioidomycosis (PCM) [ICD11:
1F2E 
, ICD11:
XN5UX ];
infection due to Paracoccidioides brasiliensis [ICD11:
XN5UX ]
The structure was elucidated in this paperNCBI PubMed ID: 8670257Publication DOI: 10.1006/bbrc.1996.0796Journal NLM ID: 0372516Publisher: Academic Press
Institutions: Perkin–Elmer Applied Biosystems Division, Foster City, USA, Department of Biochemistry, Universidade Federal de Sao Paulo/EPM, Sao Paulo, Brazil, The Biomembrane Institute, Seattle, USA, Perkin-Elmer Applied Biosystems Division, Foster City, USA
An acidic glycolipid (Band 1), purified from P. brasiliensis by a combination of ion exchange chromatography, HPLC, and HPTLC, was found to be reactive with sera of all patients with paracoccidioidomycosis (PCM). Monosaccharide analysis of Band 1 yielded mannose and galactose in a 2:1 ratio, while mild acid hydrolysis and mild periodate oxidation/NaBH4 reduction indicated the presence of a terminal galactofuranose. Preliminary analysis of 1H-NMR and MS data suggests that the structure of the glycan is Galf β 1→6 (Manp α 1→3) Manp β 1→2Ins (Ins = myo-inositol). Removal of the galacto-furanose decreased by 60-80% the reactivity of sera from PCM patients with Band 1, suggesting that this residue is immunodominant. With the presumed absence of galactofuranose in mammalian hosts, compounds containing this residue may be useful targets for therapy of several parasitic and fungal diseases.
glycolipid, Paracoccidioides brasiliensis, paracoccidioidomycosis
Structure type: oligomer
Location inside paper: p.640
Compound class: glycolipid
Contained glycoepitopes: IEDB_130701,IEDB_137485,IEDB_144983,IEDB_152206,IEDB_983930,SB_197,SB_44,SB_67,SB_72
Methods: 1H NMR, periodate oxidation, NMR-2D, FAB-MS, ESI-MS, biological assays, NMR-1D, HPLC, extraction, HPTLC, TOCSY, hydrolysis, reduction with NaBH4, CC, ESI-CID-MS/MS, COSY, NOESY, RECSY
Biological activity: possesses of 60–80% of the reactivity of sera of all patients with paracoccidioidomycosis compared with id43697
Related record ID(s): 42250, 43703, 107105
NCBI Taxonomy refs (TaxIDs): 121759
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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