Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Organ / tissue: cell wall
NCBI PubMed ID: 19519160Publication DOI: 10.1080/15476910802604317Journal NLM ID: 101201960Publisher: London: Informa Healthcare
Correspondence: Vaclav.vetvicka
louisville.edu
Institutions: Department of Pathology, University of Louisville, Louisville, USA
The objective of this study is to investigate the effects of two different yeast-derived beta-glucans on macrophage functionality and blood cholesterol levels in mice. After establishing their ability to act as a strong stimulator of macrophages, we measured the capacities of the glucans to lower blood cholesterol. Our results showed that consumption of diets containing yeast-derived beta-glucan indicated a dose-dependent decrease in plasma cholesterol levels, with Betamune having a significantly stronger effect than WGP (Whole Glucan Particles). In hypercholesterolemic subjects, the cholesterol- and triglycerides-lowering effects of Betamune were again significantly stronger. The results of this investigation demonstrated that highly purified yeast-derived β-glucans modify plasma cholesterol levels and other indicators associated with artherogenic progression in mice. The fact that these glucans also strongly stimulated both monocytes and macrophages supports the hypothesis that there could be a macrophage-cholesterol (metabolism) axis involvement in these outcomes.
blood, glucan, cholesterol, nutrition, immunocytes
Structure type: fragment of a bigger structure
Location inside paper: p.31, Betamune, WGP
Trivial name: glucan particle, PFLP
Compound class: cell wall polysaccharide, glucan
Contained glycoepitopes: IEDB_1397514,IEDB_142488,IEDB_146664,IEDB_153543,IEDB_158555,IEDB_161166,IEDB_2278476,IEDB_2278477,IEDB_558869,IEDB_857743,IEDB_983931,SB_192
Methods: biological assays
Biological activity: Betamune showed stronger and longer-lasting stimulation of the cells of the macrophage lineage than WGP; Betamune lowered the triglyceride levels in all tested intervals (400 mg/mouse), WGP glucan showed no significant activity; Betamune loweres levels of cholesterol in all tested time intervals (10–40 days), the effects of WGP were significant only at Day 20; in the case of tryglycerides: the effects of Betamune were faster, but 20 days after glucan-feeding both glucans (and both doses) were able to significantly lower the levels of tryglycerides in blood
Comments, role: Betamune from Biorigin (Sao Paulo, Brazil); WGP from Biothera (Eagan, MN)
Related record ID(s): 41223, 41287, 43337
NCBI Taxonomy refs (TaxIDs): 4932Reference(s) to other database(s): GTC:G51056AN
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There is only one chemically distinct structure:
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