Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
Organ / tissue: capsuleAssociated disease: infection due to Cryptococcus neoformans [ICD11:
XN3EH 
]
NCBI PubMed ID: 6209768Journal NLM ID: 7905878Publisher: Chicago, IL: University Of Chicago Press
Institutions: National Institute of Arthritis, Metabolism, and Digestive Diseases and Kidney, National Institutes of Health, Bethesda, USA, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA
Polysaccharides of Cryptococcus neoformans are considered to have a role in the virulence of this encapsulated fungus. The structure has been determined for the most abundant polysaccharide, a glucuronoxylomannan of varying xylose and ester content. The structural complexity of the capsular material increases from serotype D to A to B to C, but even for the simplest capsule (type D), the immunodeterminants seem to occur only on the side chains. The interactions of some of these groups with antibodies is discussed
carbohydrates, immunology, Bacterial polysaccharide, serotyping, Cryptococcus neoformans, cryptococcosis
Structure type: suggested polymer biological repeating unit ; 1400000
Location inside paper: Table 1, A
Compound class: O-polysaccharide, glucuronoxylomannan
Contained glycoepitopes: IEDB_114701,IEDB_115136,IEDB_115576,IEDB_130701,IEDB_140116,IEDB_140630,IEDB_144983,IEDB_145668,IEDB_152206,IEDB_164174,IEDB_167188,IEDB_174332,IEDB_2270799,IEDB_423153,IEDB_76933,IEDB_983930,SB_197,SB_44,SB_67,SB_72
Comments, role: the degree of O-acetylation is 12 %. the O-acetyl groups are probably located at C-6 of the mannosyl residues of the backbone; chemical repeating unit frame was shifted in annotation for compatibility with structures elucidated by MS [Eukaryotic Cell 2007, 6: 1464-1473]
Related record ID(s): 40815, 42129, 43807, 43819
NCBI Taxonomy refs (TaxIDs): 178876Reference(s) to other database(s): GTC:G75580HK
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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(later renamed to: Cryptococcus neoformans var. grubii)