Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
NCBI PubMed ID: 22186222Publication DOI: 10.1016/j.copbio.2011.11.030Journal NLM ID: 9100492Publisher: London: Elsevier
Correspondence: gregg.beckham
nrel.gov
Institutions: National Bioenergy Center, National Renewable Energy Laboratory, Golden, USA, Department of Chemical Engineering, Colorado School of Mines, Golden, USA, Chemical and Biological Process Development Group, Pacific Northwest National Laboratory, Richland, USA, Biosciences Center, National Renewable Energy Laboratory, Golden, USA, Department of Plant Biology, University of Georgia, Athens, USA
Cellulases and hemicellulases are responsible for the turnover of plant cell wall polysaccharides in the biosphere, and thus form the foundation of enzyme engineering efforts in biofuels research. Many of these carbohydrate-active enzymes from filamentous fungi contain both N-linked and O-linked glycosylation, the extent and heterogeneity of which depends on growth conditions, expression host, and the presence of glycan trimming enzymes in the secretome, all of which in turn impact enzyme activity. As the roles of glycosylation in enzyme function have not been fully elucidated, here we discuss the potential roles of glycosylation on glycoside hydrolase enzyme structure and function after secretion. We posit that glycosylation, instead of hindering cellulase engineering, can be used as an additional tool to enhance enzyme activity, given deeper understanding of its molecular-level role in biomass deconstruction.
carbohydrates, glycosylation, N-linked, O-linked, Glycoside Hydrolases, esterification, plant cell culture
Structure type: oligomer
Location inside paper: Fig.1, Cel6A, Cel7A
Aglycon: protein
Compound class: O-glycan
Contained glycoepitopes: IEDB_130701,IEDB_136104,IEDB_143632,IEDB_144983,IEDB_152206,IEDB_983930,SB_136,SB_196,SB_44,SB_67,SB_72
Related record ID(s): 43854, 43855, 43857, 43858
NCBI Taxonomy refs (TaxIDs): 51453
Show glycosyltransferases
There is only one chemically distinct structure:
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(previously named: Hypocrea jecorina)