Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
Associated disease: infection due to Cryptococcus neoformans [ICD11:
XN3EH 
]
NCBI PubMed ID: 17693597Publication DOI: 10.1128/EC.00208-07Journal NLM ID: 101130731Publisher: American Society for Microbiology
Correspondence: delpoeta
musc.edu
Institutions: Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, USA, Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, USA, Division of Infectious Diseases, Medical University of South Carolina, Charleston, USA, Dipartimento di Sanitá Pubblica—Microbiologia-Virologia, Universitá degli Studi di Milano, Milan, Italy
This review summarizes the current understanding of the role of sphingolipid biosynthesis in the pathobiology of cryptococcosis, focusing on the production and functions of the antigenic glycosphingolipid (GSL) glucosylceramide (GlcCer) and its role in the host-pathogen interaction. In addition, the presence of GlcCer and structurally similar molecules present in other pathogens will be discussed and highlighted for their importance as potential therapeutic targets.
biosurfactant, Cryptococcus neoformans, glucosylceramide, fungus antibody
Structure type: monomer
Location inside paper: p.1718, Fig.1, minor GlcCer species in Cn
Compound class: cerebroside
Contained glycoepitopes: IEDB_137339,IEDB_141181,IEDB_142488,IEDB_146664,IEDB_534865,IEDB_983931,SB_192,SB_5
Enzymes that release or process the structure: Gcs1
Related record ID(s): 43940
NCBI Taxonomy refs (TaxIDs): 5207
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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