Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
The structure was elucidated in this paperNCBI PubMed ID: 9063967Publication DOI: 10.1271/bbb.60.213Journal NLM ID: 9205717Publisher: Japan Society for Bioscience, Biotechnology, and Agrochemistry
Institutions: Kanan Women’s University, Kobe, Japan, Department of Food and Nutrition, Faculty of Human Life Science, Osaka City University, Osaka, Japan
A heteropolysaccharide and a β-D-glucan were isolated from a lichen, Gyrophora esculenta Miyoshi (Iwatake), by cold water and alkali extractions, respectively. The chemical properties of purified polysaccharides were examined by acid hydrolysis, methylation, and GC-MS. The heteropolysaccharide is a highly branched galactomannan-type polysaccharide, containing an α-(1→6)-linked D-mannan backbone, and the glucan is a linear (1→6)-β-D-glucan. With regard to the antitumor activity, both the galactomannan and (1→6)-β-D-glucan had moderate inhibition activities on Sarcoma 180, but lower than those of branched (1→3)-β-D-glucans.
polysaccharide, chemical structure, antitumor activity, lichen
Structure type: homopolymer ; 20000-30000
Location inside paper: p.215, column 1, paragraph 1, CA-2-II
Compound class: O-polysaccharide, glucan
Contained glycoepitopes: IEDB_135614,IEDB_141806,IEDB_142488,IEDB_146664,IEDB_241101,IEDB_983931,SB_192
Methods: methylation, GC-MS, acid hydrolysis, GLC, enzymatic digestion, optical rotation measurement, acetylation, reduction, CC, phenol-sulfuric acid assay, antitumor activity assay
Biological activity: intraperitoneal administration of the glycan shows antitumor activity on Sarcoma 180 solid tumors implanted in ICR-JCL mice; glucan showed 43.8% tumor inhibition ratio
Related record ID(s): 44217, 44218, 44219, 44220
NCBI Taxonomy refs (TaxIDs): 161684Reference(s) to other database(s): GTC:G26777BZ
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There is only one chemically distinct structure:
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(later renamed to: Umbilicaria esculenta)