Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
Organ / tissue: capsuleAssociated disease: infection due to Cryptococcus neoformans [ICD11:
XN3EH 
];
infection due to Cryptococcus gattii [ICD11:
XN0LE ]
Publication DOI: 10.1007/978-3-642-76074-7_10Publisher: Springer, Berlin, Heidelberg
Editors: Latge JP, Boucias D
Institutions: Department of Chemistry, Laboratory of Microbial and Biochemical Sciences, Georgia State University, Atlanta, USA
Cryptococcus neoformans is the major etiologic agent of cryptococcosis. Although usually a pulmonary pathogen, C. neoformans frequently disseminates to the central nervous system. The organism has emerged as a primary cause of opportunistic infections associated with Acquired Immunodeficiency Syndrome (AIDS). Up to 9% of patients with AIDS or AIDS related complex have been reported to have cryptococcosis (Dismukes, 1988). The Centers for Disease Control, U.S.A. (CDC), projects that 390,000 to 480,000 cases of AIDS will be reported by the end of 1993. The CDC-AIDS Program, reported 28,406 cases of AIDS in the U.S.A. for 1988; 1632 (5.75%) of that number had cryptococcosis. CDC expects approximately 52,000 new cases of AIDS to be reported in 1990. If the current trend of presentation of cryptococcosis in AIDS patients continues in 1990, then the U.S.A. can expect about 3,000 new cases of cryptococcosis associated with AIDS in 1990.
methylation analysis, capsular polysaccharide, glucuronic acid, Cryptococcus neoformans, nuclear magnetic resonance spectrum, major resonance
Structure type: suggested polymer biological repeating unit
Location inside paper: Fig.1, structure 3, GXM
Trivial name: glucuronoxylomannan (GXM), glucuronoxylomannan
Compound class: CPS, EPS, O-polysaccharide, O-antigen, cell wall polysaccharide, polysaccharide, glucuronoxylomannan, capsule polysaccharide
Contained glycoepitopes: IEDB_114701,IEDB_115136,IEDB_115576,IEDB_130701,IEDB_140116,IEDB_140630,IEDB_144983,IEDB_145668,IEDB_152206,IEDB_164174,IEDB_167188,IEDB_174332,IEDB_2270799,IEDB_423153,IEDB_76933,IEDB_983930,SB_197,SB_44,SB_67,SB_72
Methods: 13C NMR, GLC-MS
Comments, role: chemical repeating unit frame was shifted in annotation for compatibility with structures elucidated by MS [Eukaryotic Cell 2007, 6: 1464-1473]
Related record ID(s): 40816, 42130, 43808, 43816, 43822, 43825, 43917, 44110, 44281, 44283, 44284, 44285, 44287, 44288, 44289, 44351
NCBI Taxonomy refs (TaxIDs): 37769Reference(s) to other database(s): GTC:G42955PN
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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(later renamed to: Cryptococcus gattii VGI B)