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Taxonomic group: fungi / Basidiomycota (Phylum: Basidiomycota)
Organ / tissue: capsule
Associated disease: infection due to Cryptococcus neoformans [ICD11: XN3EH

]

Publication DOI: 10.1007/978-3-642-76074-7_10
Publisher: Springer, Berlin, Heidelberg
Editors: Latge JP, Boucias D
Institutions: Department of Chemistry, Laboratory of Microbial and Biochemical Sciences, Georgia State University, Atlanta, USA

Cryptococcus neoformans is the major etiologic agent of cryptococcosis. Although usually a pulmonary pathogen, C. neoformans frequently disseminates to the central nervous system. The organism has emerged as a primary cause of opportunistic infections associated with Acquired Immunodeficiency Syndrome (AIDS). Up to 9% of patients with AIDS or AIDS related complex have been reported to have cryptococcosis (Dismukes, 1988). The Centers for Disease Control, U.S.A. (CDC), projects that 390,000 to 480,000 cases of AIDS will be reported by the end of 1993. The CDC-AIDS Program, reported 28,406 cases of AIDS in the U.S.A. for 1988; 1632 (5.75%) of that number had cryptococcosis. CDC expects approximately 52,000 new cases of AIDS to be reported in 1990. If the current trend of presentation of cryptococcosis in AIDS patients continues in 1990, then the U.S.A. can expect about 3,000 new cases of cryptococcosis associated with AIDS in 1990.

methylation analysis, capsular polysaccharide, glucuronic acid, Cryptococcus neoformans, nuclear magnetic resonance spectrum, major resonance

Structure type: structural motif or average structure
Location inside paper: p.140, structure 6
Trivial name: glucuronoxylomannan (GXM)
Compound class: O-polysaccharide, glucuronoxylomannan
Contained glycoepitopes: IEDB_114701,IEDB_115136,IEDB_115576,IEDB_130701,IEDB_140116,IEDB_140630,IEDB_144983,IEDB_145668,IEDB_152206,IEDB_164174,IEDB_167188,IEDB_174332,IEDB_423153,IEDB_76933,IEDB_983930,SB_197,SB_44,SB_67,SB_72

Methods: 13C NMR, GLC-MS
Comments, role: chemical repeating unit frame was shifted to fit the biological context; misprints in the first xylopyranosyl and in the second glucuronic acid residues

Related record ID(s): 44284, 44285, 44286, 44287, 44288
NCBI Taxonomy refs (TaxIDs): 40410
Reference(s) to other database(s): GTC:G69933VF
Show glycosyltransferases

There is only one chemically distinct structure:

*O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@H]2[C@H](O)[C@@H](O[C@@H]3[C@H](O[C@@H]4O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](O[C@@H]4[C@H](O)[C@@H](O[C@@H]5[C@H](O)[C@@H](O[C@@H]6[C@H](O[C@@H]7OC[C@@H](O)[C@H](O)[C@H]7O)[C@@H](O[C@H]7[C@H](O)[C@@H](CO)O[C@H](*)[C@H]7O[C@@H]7OC[C@@H](O)[C@H](O)[C@H]7O)O[C@H](CO)[C@H]6O)O[C@H](CO)[C@H]5O)O[C@H](CO)[C@H]4O)O[C@H](CO)[C@H]3O)O[C@H](CO)[C@H]2O)[C@H]1O[C@@H]1O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]1O

SVG MW SMILES 3D mol Ionize